Myostatin

MSTN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3HH2, 3SEK
Identifiers
Aliases	MSTN, GDF8, MSLHP, myostatin
External IDs	OMIM: 601788 MGI: 95691 HomoloGene: 3850 GeneCards: MSTN
Gene ontology Molecular function • cytokine activity • heparin binding • protein binding • identical protein binding • transforming growth factor beta receptor binding • growth factor activity • receptor binding • protein homodimerization activity Cellular component • cytoplasm • extracellular region • extracellular space Biological process • regulation of apoptotic process • negative regulation of protein kinase B signaling • negative regulation of myoblast differentiation • regulation of MAPK cascade • SMAD protein signal transduction • muscle cell cellular homeostasis • cell development • response to testosterone • positive regulation of pathway-restricted SMAD protein phosphorylation • muscle organ development • response to glucocorticoid • response to heat • response to electrical stimulus • negative regulation of myoblast proliferation • ovulation cycle process • cellular response to dexamethasone stimulus • negative regulation of muscle hypertrophy • response to estrogen • negative regulation of skeletal muscle satellite cell proliferation • positive regulation of transcription, DNA-templated • response to gravity • negative regulation of insulin receptor signaling pathway • skeletal muscle tissue regeneration • skeletal muscle atrophy • negative regulation of satellite cell differentiation • response to ethanol • negative regulation of skeletal muscle tissue growth • transforming growth factor beta receptor signaling pathway • response to muscle activity • negative regulation of kinase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2660	17700
Ensembl	ENSG00000138379	ENSMUSG00000026100
UniProt	O14793	O08689
RefSeq (mRNA)	NM_005259	NM_010834
RefSeq (protein)	NP_005250	NP_034964.1 NP_034964
Location (UCSC)	Chr 2: 190.06 – 190.06 Mb	Chr 1: 53.06 – 53.07 Mb
PubMed search

3HH2, 3SEK

2660

17700

ENSG00000138379

ENSMUSG00000026100

O14793

O08689

NM_005259

NM_010834

NP_005250

NP_034964.1
NP_034964

Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.

Animals either lacking myostatin or treated with substances that block the activity of myostatin have significantly more muscle mass. Furthermore, individuals who have mutations in both copies of the myostatin gene have significantly more muscle mass and are stronger than normal. There is hope that studies into myostatin may have therapeutic application in treating muscle wasting diseases such as muscular dystrophy.

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