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Myostatin

MSTN
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MSTN, GDF8, MSLHP, myostatin
External IDs OMIM: 601788 MGI: 95691 HomoloGene: 3850 GeneCards: MSTN
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005259

NM_010834

RefSeq (protein)

NP_005250

NP_034964.1
NP_034964

Location (UCSC) Chr 2: 190.06 – 190.06 Mb Chr 1: 53.06 – 53.07 Mb
PubMed search

3HH2, 3SEK

NM_005259

NM_010834

NP_005250

NP_034964.1
NP_034964

Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.

Animals either lacking myostatin or treated with substances that block the activity of myostatin have significantly more muscle mass. Furthermore, individuals who have mutations in both copies of the myostatin gene have significantly more muscle mass and are stronger than normal. There is hope that studies into myostatin may have therapeutic application in treating muscle wasting diseases such as muscular dystrophy.


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