GATA-1

GATA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GNF, 1Y0J, 2L5E, 2L6Y, 2L6Z, 3VD6, 3VEK
Identifiers
Aliases	GATA1, ERYF1, GATA-1, GF-1, GF1, NF-E1, NFE1, XLANP, XLTDA, XLTT, GATA binding protein 1
External IDs	OMIM: 305371 MGI: 95661 HomoloGene: 1549 GeneCards: GATA1
Gene location (Human) Chr. X chromosome (human) Band Xp11.23 Start 48,786,554 bp End 48,794,311 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X A1.1|X 3.59 cM Start 7,959,260 bp End 7,978,071 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • C2H2 zinc finger domain binding • core promoter binding • transcription regulatory region sequence-specific DNA binding • sequence-specific DNA binding • RNA polymerase II core promoter sequence-specific DNA binding • DNA binding • p53 binding • DNA binding, bending • RNA polymerase II transcription factor binding • chromatin DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • enhancer sequence-specific DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • chromatin binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • zinc ion binding • metal ion binding Cellular component • nucleus • nucleoplasm • transcriptional repressor complex • transcription factor complex • protein-DNA complex Biological process • negative regulation of cell proliferation • negative regulation of transcription regulatory region DNA binding • eosinophil fate commitment • in utero embryonic development • regulation of glycoprotein biosynthetic process • cellular response to thyroid hormone stimulus • blood coagulation • erythrocyte differentiation • platelet formation • positive regulation of osteoblast proliferation • transcription from RNA polymerase II promoter • platelet aggregation • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • regulation of transcription, DNA-templated • regulation of primitive erythrocyte differentiation • positive regulation of transcription, DNA-templated • regulation of definitive erythrocyte differentiation • transcriptional activation by promoter-enhancer looping • cell-cell signaling • embryonic hemopoiesis • cell development • positive regulation of erythrocyte differentiation • positive regulation of transcription from RNA polymerase II promoter • megakaryocyte differentiation • dendritic cell differentiation • positive regulation of peptidyl-tyrosine phosphorylation • negative regulation of bone mineralization • negative regulation of transcription from RNA polymerase II promoter • male gonad development • myeloid cell differentiation • negative regulation of apoptotic process • homeostasis of number of cells within a tissue • transcription, DNA-templated • basophil differentiation • eosinophil differentiation • erythrocyte development • regulation of megakaryocyte differentiation • regulation of hematopoietic stem cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2623	14460
Ensembl	ENSG00000102145	ENSMUSG00000031162
UniProt	P15976	P17679
RefSeq (mRNA)	NM_002049	NM_008089
RefSeq (protein)	NP_002040	NP_032115
Location (UCSC)	Chr X: 48.79 – 48.79 Mb	Chr X: 7.96 – 7.98 Mb
PubMed search

1GNF, 1Y0J, 2L5E, 2L6Y, 2L6Z, 3VD6, 3VEK

2623

14460

ENSG00000102145

ENSMUSG00000031162

P15976

P17679

NM_002049

NM_008089

NP_002040

NP_032115

Erythroid transcription factor also known as GATA-binding factor 1 or GATA-1 is a protein that in humans is encoded by the GATA1 gene.

GATA-1 is a member of the GATA transcription factor family and is a key mediator of the development of specific types of blood cells from their precursor cells, termed hematopoietic progenitors or precursors. This protein plays a role in erythroid development by regulating a large ensemble of genes that mediate both the development and function of red blood cells. Critical functions in the developing red blood cell (erythroblast) include the establishment of the erythroid cytoskeleton, enzymes that mediate heme biosynthesis, and polypeptide chains that constitute the hemoglobin tetramer. Mutations in the gene encoding GATA-1 have been associated with X-linked dyserythropoietic anemia and thrombocytopenia.

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