GAS6

GAS6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H30, 2C5D, 4RA0
Identifiers
Aliases	GAS6, AXLLG, AXSF, growth arrest specific 6
External IDs	MGI: 95660 HomoloGene: 638 GeneCards: GAS6
Gene ontology Molecular function • protein binding • receptor binding • receptor tyrosine kinase binding • voltage-gated calcium channel activity • receptor agonist activity • binding, bridging • phosphatidylserine binding • metal ion binding • protein tyrosine kinase activator activity • calcium ion binding • cysteine-type endopeptidase inhibitor activity involved in apoptotic process Cellular component • endoplasmic reticulum lumen • cytoplasm • Golgi lumen • platelet alpha granule lumen • extracellular exosome • extracellular region • intracellular • extracellular space Biological process • positive regulation of natural killer cell differentiation • apoptotic cell clearance • negative regulation of interleukin-1 secretion • cellular response to vitamin K • negative regulation of sequence-specific DNA binding transcription factor activity • positive regulation of protein kinase activity • negative regulation of biomineral tissue development • negative regulation of tumor necrosis factor-mediated signaling pathway • fusion of virus membrane with host plasma membrane • cellular response to starvation • negative regulation of interleukin-6 secretion • positive regulation of phagocytosis • positive regulation of protein kinase B signaling • cell cycle arrest • positive regulation of cytokine-mediated signaling pathway • positive regulation of gene expression • dendritic cell differentiation • neuron migration • cell adhesion • protein kinase B signaling • positive regulation of glomerular filtration • B cell chemotaxis • negative regulation of apoptotic process • positive regulation of ERK1 and ERK2 cascade • phagocytosis • regulation of growth • activation of protein kinase B activity • negative regulation of tumor necrosis factor production • platelet degranulation • viral entry into host cell • negative regulation of oligodendrocyte apoptotic process • leukocyte migration • enzyme linked receptor protein signaling pathway • positive regulation of protein tyrosine kinase activity • cell migration • platelet activation • negative regulation of transcription, DNA-templated • positive regulation of protein export from nucleus • protein targeting to plasma membrane • animal organ regeneration • cellular response to growth factor stimulus • negative regulation of interferon-gamma production • macrophage cytokine production • cellular response to glucose stimulus • hematopoietic stem cell migration to bone marrow • negative regulation of dendritic cell apoptotic process • calcium ion transmembrane transport • cell-substrate adhesion • negative regulation of interleukin-6 production • positive regulation of dendritic cell chemotaxis • signal peptide processing • viral genome replication • cell proliferation • positive regulation of fibroblast proliferation • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of fibroblast apoptotic process • positive regulation of peptidyl-serine phosphorylation • cellular response to drug • platelet aggregation • positive regulation of TOR signaling • peptidyl-serine phosphorylation • negative regulation of protein import into nucleus, translocation • receptor-mediated virion attachment to host cell • ER to Golgi vesicle-mediated transport • viral process • extracellular matrix assembly • cellular response to interferon-alpha • protein phosphorylation • negative regulation of renal albumin absorption • negative regulation of endothelial cell apoptotic process • positive regulation of protein phosphorylation • signal transduction • blood coagulation • apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2621	14456
Ensembl	ENSG00000183087	ENSMUSG00000031451
UniProt	Q14393	Q61592
RefSeq (mRNA)	NM_001143946 NM_000820 NM_001143945	NM_019521
RefSeq (protein)	NP_000811	NP_062394.2 NP_062394
Location (UCSC)	Chr 13: 113.82 – 113.86 Mb	Chr 8: 13.47 – 13.49 Mb
PubMed search

1H30, 2C5D, 4RA0

2621

14456

ENSG00000183087

ENSMUSG00000031451

Q14393

Q61592

NM_001143946
NM_000820
NM_001143945

NM_019521

NP_000811

NP_062394.2
NP_062394

Growth arrest-specific 6, also known as GAS6, is a human gene coding for the Gas6 protein. It is similar to the Protein S with the same domain organization and 43% amino acid identity. It was originally found as a gene upregulated by growth arrested fibroblasts.

Gas6 is a gamma-carboxyglutamic acid (Gla) domain-containing protein thought to be involved in the stimulation of cell proliferation.

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