GABRA2

GABRA2
Identifiers
Aliases	GABRA2, gamma-aminobutyric acid type A receptor alpha2 subunit
External IDs	MGI: 95614 HomoloGene: 20217 GeneCards: GABRA2
Gene ontology Molecular function • GABA-A receptor activity • ion channel activity • benzodiazepine receptor activity • extracellular ligand-gated ion channel activity • chloride channel activity • GABA-gated chloride ion channel activity Cellular component • integral component of membrane • chloride channel complex • membrane • synapse • plasma membrane • cell junction • integral component of synaptic vesicle membrane • postsynaptic membrane • cytoplasmic vesicle membrane • cytoplasmic vesicle • GABA-A receptor complex Biological process • gamma-aminobutyric acid signaling pathway • chloride transport • ion transmembrane transport • regulation of neurotransmitter levels • neurotransmitter transport • transport • ion transport • chloride transmembrane transport • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2555	14395
Ensembl	ENSG00000151834	ENSMUSG00000000560
UniProt	P47869	P26048
RefSeq (mRNA)	NM_000807 NM_001114175 NM_001286827 NM_001330690	NM_008066
RefSeq (protein)	NP_000798 NP_001107647 NP_001273756 NP_001317619	NP_032092.1 NP_032092
Location (UCSC)	Chr 4: 46.25 – 46.48 Mb	Chr 5: 70.96 – 71.1 Mb
PubMed search

2555

14395

ENSG00000151834

ENSMUSG00000000560

P47869

P26048

NM_000807
NM_001114175
NM_001286827
NM_001330690

NM_008066

NP_000798
NP_001107647
NP_001273756
NP_001317619

NP_032092.1
NP_032092

Gamma-aminobutyric acid receptor subunit alpha-2 is a protein in humans that is encoded by the GABRA2 gene.

GABRA2 is an alpha subunit that is part of GABA-A receptors, which are ligand-gated chloride channels and are activated by the major inhibitory neurotransmitter in the mammalian brain, GABA. Chloride conductance of these channels can be modulated by agents, such as benzodiazepines (psychoactive drugs) that bind to the GABA-A receptor.

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