Francisco Palóu (1723–1789) was a Spanish Franciscan missionary, administrator and historian on the Baja California Peninsula and in Alta California. Palóu made significant contributions to the Alta California and Baja California mission systems. Along with his mentor, Junípero Serra, Palóu worked to build numerous missions throughout Alta and Baja California, many structures of which still stand today. A member of the Franciscan Order, Palóu became "Presidente" of the missions in Baja California, and later of missions of Alta California. Palóu's work in the Spanish mission system spans from his early twenties to his death at the age of 66.
According to biographer Herbert E. Bolton, "Fray Palóu was a diligent student, devout Christian, loyal disciple, tireless traveler, zealous missionary, firm defender of the faith, resourceful pioneer, successful mission builder, able administrator, and fair minded historian of California". Palóu is particularly noted for his pious biography of Serra and for his multi-volume early history of the Californias.
Francisco (born Francesc) Palóu was born in Palma, Majorca, Spain, where he joined the Franciscan Order. Together with Junípero Serra, he traveled to New Spain in 1740 and served as a missionary in the Sierra Gorda region of Querétaro. When the Jesuits were expelled from Baja California in 1768, the Franciscans under Serra were sent to replace them. Palóu was assigned to the mission of San Javier. The following year, Serra went north to find the new mission province of Alta California, and Palóu succeeded him as head of the Baja California missions. When the Dominicans took over the peninsular Baja California missions in 1773, Palóu, being Franciscan, moved on to Upper California, marking the geographical boundary between the two orders' fields. He assisted in the exploration of the site of San Francisco and administered Mission San Francisco de Asís. When Serra died, Palóu was briefly acting head of the Baja California missions, but soon returned to central Mexico.