Francesco Ferruccio (or Ferrucci) (1489 – August 3, 1530) was an Italian captain from Florence who fought in the Italian Wars.
After spending a few years as a merchant's clerk he took to soldiering at an early age, and served his apprenticeship under Giovanni de' Medici, in the latter's Black Bands (Delle Bande Nere being Giovanni de' Medici's nickname, from the black stripes on his insignia) in various parts of Italy, earning a reputation as a daring fighter and swashbuckler. When Pope Clement VII and the emperor Charles V decided to reinstate the Medici in Florence, during the War of the League of Cognac, they attacked the Florentine republic, and Ferruccio was appointed Florentine military commissioner, where he showed great daring and resource by his rapid marches and sudden attacks on the Imperials.
Early in 1530 Volterra had thrown off Florentine allegiance and had been occupied by an Imperial garrison, but Ferruccio surprised and recaptured the city. During his absence, however, the Imperials captured Empoli by treachery, thus cutting off one of the chief avenues of approach to Florence. Ferruccio proposed to the government of the Republic that he should march on Rome and terrorize the Pope by the threat of a sack into making peace with Florence on favorable terms, but although the war committee appointed him commissioner-general for the operations outside the city, they rejected his scheme as too audacious.
Ferruccio then decided to attempt a diversion by attacking the Imperials in the rear and started from Volterra for the Apennines. But at Pisa he was laid up for a month with a fever, which enabled the enemy to get wind of his plan and to prepare for his attack. At the end of July Ferruccio left Pisa at the head of about 4,000 men. Although the besieged in Florence, knowing that a large part of the Imperialists under the Prince of Orange Philibert of Châlon, had gone to meet Ferruccio, wished to co-operate with the latter by means of a sortie, they were prevented from doing so by their own treacherous commander, Malatesta Baglioni.