The first Fort Lisa (1810-1812), also known as the Fort Manuel Lisa Trading Post, Fort Manuel or Fort Mandan, was started by the notable fur trader Manuel Lisa of the Missouri Fur Company in 1809. This fort was likely where Sacagawea died; she had been the guide for the Lewis and Clark Expedition. Fort Lisa superseded Fort Raymond as the uppermost post of the Missouri Fur Company on the Missouri River. In 1812 Lisa built a replacement fort downriver near present-day North Omaha, Nebraska, which he also named Fort Lisa.
In the winter of 1807, Lisa opened Fort Raymond at the mouth of the Bighorn River in modern Montana. After returning to St. Louis the following year, he formed the Missouri Fur Company with local luminaries such as William Clark and members of the Chouteau family, founders of St. Louis. With company assets allowing a large party of 300 men, Lisa left in 1809 on a fur expedition in the north. After visiting Fort Raymond, he built a new station named Fort Lisa and shifted operations to the new post. The new station was located near a Gros Ventres village, in between the mouth of the Little Missouri and that of the Big Knife rivers in what is now North Dakota. During its first year of operation Pierre Dorion, Jr., his common law wife Marie Aioe Dorion and family resided at the station.