Focal-adhesion kinase

PTK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4Q9S, 1K04, 1K05, 1MP8, 1OW6, 1OW7, 1OW8, 2ETM, 2IJM, 3B71, 3BZ3, 3PXK, 3S9O, 4EBV, 4EBW, 4GU6, 4GU9, 4I4E, 4I4F, 4K8A, 4K9Y, 4KAB, 4KAO, 4NY0
Identifiers
Aliases	PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, protein tyrosine kinase 2
External IDs	OMIM: 600758 MGI: 95481 HomoloGene: 7314 GeneCards: PTK2
Gene location (Human) Chr. Chromosome 8 (human) Band n/a Start 140,657,900 bp End 141,002,216 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band n/a Start 73,205,105 bp End 73,423,191 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • SH2 domain binding • kinase activity • receptor binding • ATP binding • protein kinase activity • JUN kinase binding • non-membrane spanning protein tyrosine kinase activity • transferase activity • protein binding • protein kinase binding • nucleotide binding • signal transducer activity • actin binding • Ras guanyl-nucleotide exchange factor activity • protein tyrosine kinase activity Cellular component • cytoplasm • cytosol • membrane • focal adhesion • extrinsic component of cytoplasmic side of plasma membrane • microtubule organizing center • cytoskeleton • nucleus • stress fiber • apical plasma membrane • lamellipodium • plasma • cell cortex • cell junction Biological process • regulation of protein phosphorylation • positive regulation of protein phosphorylation • regulation of cell adhesion mediated by integrin • embryo development • placenta development • vasculogenesis • protein phosphorylation • vascular endothelial growth factor receptor signaling pathway • growth hormone receptor signaling pathway • blood vessel development • regulation of osteoblast differentiation • angiogenesis • transforming growth factor beta receptor signaling pathway • cellular response to transforming growth factor beta stimulus • positive regulation of protein kinase B signaling • Fc-gamma receptor signaling pathway involved in phagocytosis • cell motility • regulation of GTPase activity • signal complex assembly • regulation of epithelial cell migration • negative regulation of axonogenesis • regulation of endothelial cell migration • establishment of cell polarity • regulation of focal adhesion assembly • phosphorylation • netrin-activated signaling pathway • negative regulation of synapse assembly • extracellular matrix organization • negative regulation of apoptotic process • neuron migration • positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process • regulation of cell shape • peptidyl-tyrosine autophosphorylation • integrin-mediated signaling pathway • regulation of substrate adhesion-dependent cell spreading • negative regulation of organ growth • microtubule cytoskeleton organization • negative regulation of anoikis • positive regulation of protein kinase activity • negative regulation of cell-cell adhesion • positive regulation of cell migration • ephrin receptor signaling pathway • heart morphogenesis • MAPK cascade • axon guidance • positive regulation of phosphatidylinositol 3-kinase activity • multicellular organism development • regulation of cell proliferation • positive regulation of cell proliferation • positive regulation of phosphatidylinositol 3-kinase signaling • regulation of cytoskeleton organization • endothelial cell migration • central nervous system neuron axonogenesis • positive regulation of GTPase activity • innate immune response • peptidyl-tyrosine phosphorylation • epidermal growth factor receptor signaling pathway • protein autophosphorylation • execution phase of apoptosis • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5747	14083
Ensembl	ENSG00000169398	ENSMUSG00000022607
UniProt	Q05397	P34152
RefSeq (mRNA)	NM_001199649 NM_005607 NM_153831 NM_001316342	NM_001130409 NM_007982
RefSeq (protein)	NP_001186578 NP_001303271 NP_005598 NP_722560 NP_001339623 NP_001339624 NP_001339625 NP_001339626 NP_001339627 NP_001339628 NP_001339629 NP_001339630 NP_001339631 NP_001339632 NP_001339633 NP_001339634 NP_001339635 NP_001339636 NP_001339637 NP_001339638 NP_001339639 NP_001339640 NP_001339641 NP_001339642 NP_001339643 NP_001339644 NP_001339645 NP_001339646 NP_001339647 NP_001339648 NP_001339649 NP_001339650 NP_001339651 NP_001339652 NP_001339653 NP_001339654 NP_001339655 NP_001339656 NP_001339657 NP_001339658 NP_001339659 NP_001339660 NP_001339661 NP_001339662 NP_001339663 NP_001339664 NP_001339665 NP_001339666 NP_001339667 NP_001339668 NP_001339669 NP_001339670 NP_001339671 NP_001339672 NP_001339673 NP_001339674 NP_001339675 NP_001339676 NP_001339677 NP_001339678 NP_001339679 NP_001339680 NP_001339681	NP_001123881 NP_032008
Location (UCSC)	Chr 8: 140.66 – 141 Mb	Chr 8: 73.21 – 73.42 Mb
PubMed search

4Q9S, 1K04, 1K05, 1MP8, 1OW6, 1OW7, 1OW8, 2ETM, 2IJM, 3B71, 3BZ3, 3PXK, 3S9O, 4EBV, 4EBW, 4GU6, 4GU9, 4I4E, 4I4F, 4K8A, 4K9Y, 4KAB, 4KAO, 4NY0

5747

14083

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