The first cholera pandemic (1817–24), also known as the first Asiatic cholera pandemic or Asiatic cholera, began near Calcutta and spread throughout Southeast Asia to the Middle East, eastern Africa and the Mediterranean coast. While cholera had spread across India many times previously, this outbreak went further; it reached as far as China and the Mediterranean Sea before receding. Hundreds of thousands of people died as a result of this pandemic, including many British soldiers, which attracted European attention. This was the first of several cholera pandemics to sweep through Asia and Europe during the 19th and 20th centuries. This first pandemic spread over an unprecedented range of territory, affecting almost every country in Asia.
Cholera was endemic to the lower Ganges River. At festival times, pilgrims frequently contracted the disease there and carried it back to other parts of India on their returns, where it would spread, then subside. The first cholera pandemic started similarly, as an outbreak that was suspected to have begun in 1817 in the town of Jessore. Some epidemiologists and medical historians have suggested that it spread globally through a Hindu pilgrimage, the Kumbh Mela, on the upper Ganges River. Earlier outbreaks of cholera had occurred near Purnia in Bihar, but scholars think these were independent events. In 1817, cholera began spreading outside the Ganges delta. By September 1817, the disease had reached Calcutta on the Bay of Bengal and quickly spread to the rest of the subcontinent. By 1818 the disease broke out in Bombay, on the west coast.
In March 1820 the disease was identified in Siam, in May 1820 it had spread as far as Bangkok and Manila, in spring of 1821 it reached Java, Oman, and Anhai in China; in 1822 it was found in Japan, in the Persian Gulf, in Baghdad, in Syria, and in the Transcaucacus; and in 1823 cholera reached Astrakhan, Zanzibar, and Mauritius.