Fimbrin

PLS1
Identifiers
Aliases	PLS1, Fimbrin
External IDs	MGI: 104809 HomoloGene: 68270 GeneCards: PLS1
Genetically Related Diseases
type 2 diabetes mellitus
Gene ontology Molecular function • calcium ion binding • actin binding • structural constituent of cytoskeleton • metal ion binding • actin filament binding Cellular component • terminal web • extracellular exosome • brush border • cytoplasm • actin filament • actin filament bundle Biological process • intestinal D-glucose absorption • regulation of microvillus length • terminal web assembly • positive regulation of multicellular organism growth • positive regulation of establishment of protein localization to plasma membrane • actin filament bundle assembly • actin filament network formation • actin crosslink formation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5357	102502
Ensembl	ENSG00000120756	ENSMUSG00000049493
UniProt	Q14651	Q3V0K9
RefSeq (mRNA)	NM_001145319 NM_001172312 NM_002670	NM_001033210
RefSeq (protein)	NP_001138791 NP_001165783 NP_002661	NP_001028382.1 NP_001028382
Location (UCSC)	Chr 3: 142.6 – 142.71 Mb	Chr 9: 95.75 – 95.85 Mb
PubMed search

5357

102502

ENSG00000120756

ENSMUSG00000049493

Q14651

Q3V0K9

NM_001145319
NM_001172312
NM_002670

NM_001033210

NP_001138791
NP_001165783
NP_002661

NP_001028382.1
NP_001028382

Fimbrin also known as is plastin 1 is a protein that in humans is encoded by the PLS1 gene. Fimbrin is an actin cross-linking protein important in the formation of filopodia.

Fimbrin belongs to the calponin homology (CH) domain superfamily of actin cross-linking proteins. Like other members of this superfamily, which include α-actinin, β-spectrin, dystrophin, ABP-120 and filamin, it has a conserved 27 kDa actin-binding domain that contains a tandem duplication of a sequence that is homologous to calponin. In addition to cross-linking actin filaments into bundles and networks, CH domains also bind intermediate filaments and some signal transduction proteins to the actin cytoskeleton. Structural comparison of actin filaments and fimbrin CH domain-decorated actin filaments has revealed changes in the actin structure due to fimbrin-mediated cross-linking that may affect the actin filaments' affinity for other actin-binding proteins and may be part of the regulation of the cytoskeleton itself.

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Wikipedia