Fibroblast growth factor 23

FGF23
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2P39
Identifiers
Aliases	FGF23, ADHR, FGFN, HPDR2, HYPF, PHPTC, fibroblast growth factor 23
External IDs	OMIM: 605380 MGI: 1891427 HomoloGene: 10771 GeneCards: FGF23
Gene ontology Molecular function • fibroblast growth factor receptor binding • type 1 fibroblast growth factor receptor binding • growth factor activity • protein tyrosine kinase activity • Ras guanyl-nucleotide exchange factor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • 1-phosphatidylinositol-3-kinase activity Cellular component • extracellular region • Golgi lumen • extracellular space Biological process • cell differentiation • negative regulation of bone mineralization • cellular response to interleukin-6 • vitamin D metabolic process • regulation of bone mineralization • phosphate ion homeostasis • cellular phosphate ion homeostasis • response to magnesium ion • regulation of phosphate transport • cellular response to vitamin D • negative regulation of osteoblast differentiation • cellular response to leptin stimulus • positive regulation of transcription, DNA-templated • fibroblast growth factor receptor signaling pathway • response to sodium phosphate • positive regulation of ERK1 and ERK2 cascade • positive regulation of vitamin D 24-hydroxylase activity • phosphate-containing compound metabolic process • vitamin D catabolic process • positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway • cellular response to parathyroid hormone stimulus • negative regulation of hormone secretion • phosphatidylinositol-mediated signaling • positive regulation of GTPase activity • phosphatidylinositol phosphorylation • peptidyl-tyrosine phosphorylation • regulation of phosphatidylinositol 3-kinase signaling • phosphatidylinositol-3-phosphate biosynthetic process • MAPK cascade Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8074	64654
Ensembl	ENSG00000118972	ENSMUSG00000000182
UniProt	Q9GZV9	Q9EPC2
RefSeq (mRNA)	NM_020638	NM_022657
RefSeq (protein)	NP_065689	NP_073148.1 NP_073148
Location (UCSC)	Chr 12: 4.37 – 4.38 Mb	Chr 6: 127.07 – 127.08 Mb
PubMed search

2P39

8074

64654

ENSG00000118972

ENSMUSG00000000182

Q9GZV9

Q9EPC2

NM_020638

NM_022657

NP_065689

NP_073148.1
NP_073148

Fibroblast growth factor 23 or FGF23 is a protein that in humans is encoded by the FGF23 gene. FGF23 is a member of the fibroblast growth factor (FGF) family which is responsible for phosphate and vitamin D metabolism.

The main function of FGF23 seems to be regulation of phosphate concentration in plasma. FGF23 is secreted by osteocytes in response to elevated calcitriol. FGF23 acts on the kidneys, where it decreases the expression of NPT2, a sodium-phosphate cotransporter in the proximal tubule. Thus, FGF23 decreases the reabsorption and increases excretion of phosphate. FGF23 may also suppress 1-alpha-hydroxylase, reducing its ability to activate vitamin D and subsequently impairing calcium absorption.

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