FRK (gene)

FRK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D8J, 2DLY
Identifiers
Aliases	FRK, GTK, PTK5, RAK, Fyn-related kinase, fyn related Src family tyrosine kinase
External IDs	MGI: 103265 HomoloGene: 48065 GeneCards: FRK
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • kinase activity • protein binding • protein tyrosine kinase activity • receptor binding • ATP binding • non-membrane spanning protein tyrosine kinase activity Cellular component • extrinsic component of cytoplasmic side of plasma membrane • plasma membrane • intracellular • extracellular exosome • extracellular region • nucleus • nucleoplasm • cytoplasm • cytosol • azurophil granule lumen • specific granule lumen Biological process • cell differentiation • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • negative regulation of transcription from RNA polymerase II promoter • protein phosphorylation • peptidyl-tyrosine autophosphorylation • innate immune response • negative regulation of cell proliferation • neutrophil degranulation • cell migration Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2444	14302
Ensembl	ENSG00000111816	ENSMUSG00000019779
UniProt	P42685	Q922K9
RefSeq (mRNA)	NM_002031	NM_001159544 NM_010237
RefSeq (protein)	NP_002022	NP_001153016.1 NP_034367.2 NP_001153016 NP_034367
Location (UCSC)	Chr 6: 115.93 – 116.06 Mb	Chr 10: 34.48 – 34.61 Mb
PubMed search

2D8J, 2DLY

2444

14302

ENSG00000111816

ENSMUSG00000019779

P42685

Q922K9

NM_002031

NM_001159544
NM_010237

NP_002022

NP_001153016.1
NP_034367.2
NP_001153016
NP_034367

Fyn-related kinase (FRK, formerly tyrosine protein kinase 5) is an enzyme that in humans is encoded by the FRK gene.

The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.

FRK has been shown to interact with retinoblastoma protein.

...
Wikipedia