Retinoblastoma protein

RB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AD6, 1GH6, 1GUX, 1H25, 1N4M, 1O9K, 1PJM, 2AZE, 2QDJ, 2R7G, 3N5U, 3POM, 4ELJ, 4ELL, 4CRI
Identifiers
Aliases	RB1, pRb, RB, retinoblastoma 1, OSRC, PPP1R130, p105-Rb, pp110, Retinoblastoma protein, RB transcriptional corepressor 1
External IDs	MGI: 97874 HomoloGene: 272 GeneCards: RB1
Gene ontology Molecular function • DNA binding • core promoter binding • transcription factor activity, sequence-specific DNA binding • transcription coactivator activity • transcription factor binding • RNA polymerase II activating transcription factor binding • phosphoprotein binding • kinase binding • protein binding • androgen receptor binding • identical protein binding • enzyme binding • ubiquitin protein ligase binding Cellular component • PML body • SWI/SNF complex • transcription factor complex • Rb-E2F complex • spindle • nucleoplasm • cyclin/CDK positive transcription elongation factor complex • chromatin • nucleus Biological process • negative regulation of cell proliferation • negative regulation of mitotic cell cycle • neuron apoptotic process • androgen receptor signaling pathway • chromatin remodeling • regulation of transcription, DNA-templated • negative regulation of smoothened signaling pathway • cell cycle checkpoint • negative regulation of protein kinase activity • cell morphogenesis involved in neuron differentiation • negative regulation of transcription involved in G1/S transition of mitotic cell cycle • mitotic cell cycle checkpoint • regulation of transcription from RNA polymerase II promoter • G1/S transition of mitotic cell cycle • positive regulation of macrophage differentiation • cellular response to xenobiotic stimulus • negative regulation of cell cycle • negative regulation of transcription from RNA polymerase II promoter • regulation of transcription involved in G1/S transition of mitotic cell cycle • negative regulation of sequence-specific DNA binding transcription factor activity • transcription, DNA-templated • glial cell apoptotic process • regulation of cohesin loading • regulation of cell cycle • neuron maturation • cell division • positive regulation of transcription, DNA-templated • negative regulation of G1/S transition of mitotic cell cycle • positive regulation of mitotic metaphase/anaphase transition • regulation of centromere complex assembly • cell cycle arrest • enucleate erythrocyte differentiation • neuron differentiation • regulation of mitotic cell cycle • negative regulation of epithelial cell proliferation • skeletal muscle cell differentiation • sister chromatid biorientation • protein localization to chromosome, centromeric region • cell cycle • striated muscle cell differentiation • Ras protein signal transduction • myoblast differentiation • viral process • negative regulation of transcription, DNA-templated • neuron projection development • digestive tract development • maintenance of mitotic sister chromatid cohesion • negative regulation of transcription from RNA polymerase II promoter during mitotic cell cycle • regulation of lipid kinase activity • positive regulation of transcription from RNA polymerase II promoter • hepatocyte apoptotic process • apoptotic process • positive regulation of transcription regulatory region DNA binding • negative regulation of gene expression • regulation of cell growth • covalent chromatin modification • tissue homeostasis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5925	19645
Ensembl	ENSG00000139687	ENSMUSG00000022105
UniProt	P06400	P13405
RefSeq (mRNA)	NM_000321	NM_009029
RefSeq (protein)	NP_000312 NP_000312.2	NP_033055.2 NP_033055
Location (UCSC)	Chr 13: 48.3 – 48.48 Mb	Chr 14: 73.18 – 73.33 Mb
PubMed search

1AD6, 1GH6, 1GUX, 1H25, 1N4M, 1O9K, 1PJM, 2AZE, 2QDJ, 2R7G, 3N5U, 3POM, 4ELJ, 4ELL, 4CRI

5925

19645

ENSG00000139687

ENSMUSG00000022105

P06400

P13405

NM_000321

NM_009029

...
Wikipedia