FOXC2

FOXC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1D5V
Identifiers
Aliases	FOXC2, FKHL14, LD, MFH-1, MFH1, forkhead box C2
External IDs	OMIM: 602402 MGI: 1347481 HomoloGene: 21091 GeneCards: FOXC2
Gene location (Human) Chr. Chromosome 16 (human) Band 16q24.1 Start 86,567,251 bp End 86,569,728 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8 E1|8 70.33 cM Start 121,116,171 bp End 121,118,895 bp
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • identical protein binding • transcription regulatory region DNA binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • chromatin DNA binding • promoter-specific chromatin binding Cellular component • nucleus • nucleoplasm • nuclear body Biological process • Notch signaling pathway • somitogenesis • embryonic skeletal system morphogenesis • skeletal system development • insulin receptor signaling pathway • ureteric bud development • regulation of blood vessel size • regulation of transcription, DNA-templated • positive regulation of cell migration involved in sprouting angiogenesis • neural crest cell development • paraxial mesoderm formation • paraxial mesodermal cell fate commitment • ossification • lymphangiogenesis • collagen fibril organization • kidney development • glomerular mesangial cell development • heart morphogenesis • negative regulation of transcription from RNA polymerase II promoter • cardiac muscle cell proliferation • lymph vessel development • transcription, DNA-templated • embryonic heart tube development • positive regulation of endothelial cell migration • positive regulation of transcription, DNA-templated • multicellular organism development • ventricular cardiac muscle tissue morphogenesis • heart development • blood vessel remodeling • vascular endothelial growth factor receptor signaling pathway • blood vessel development • positive regulation of vascular wound healing • artery morphogenesis • branching involved in blood vessel morphogenesis • glomerular visceral epithelial cell differentiation • response to hormone • embryonic viscerocranium morphogenesis • embryonic cranial skeleton morphogenesis • camera-type eye development • glomerular endothelium development • positive regulation of cell adhesion mediated by integrin • mesoderm development • regulation of organ growth • metanephros development • cell proliferation • positive regulation of transcription from RNA polymerase II promoter • negative regulation of apoptotic process involved in outflow tract morphogenesis • transcription from RNA polymerase II promoter • cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2303	14234
Ensembl	ENSG00000176692	ENSMUSG00000046714
UniProt	Q99958	Q61850
RefSeq (mRNA)	NM_005251	NM_013519
RefSeq (protein)	NP_005242	NP_038547
Location (UCSC)	Chr 16: 86.57 – 86.57 Mb	Chr 16: 121.12 – 121.12 Mb
PubMed search

1D5V

2303

14234

ENSG00000176692

ENSMUSG00000046714

Q99958

Q61850

NM_005251

NM_013519

NP_005242

NP_038547

Forkhead box protein C2 (FOXC2) also known as forkhead-related protein FKHL14 (FKHL14), transcription factor FKH-14, or mesenchyme fork head protein 1 (MFH1) is a protein that in humans is encoded by the FOXC2 gene. FOXC2 is a member of the fork head box (FOX) family of transcription factors.

The protein is 501 amino acids in length. The gene has no introns; the single exon is approximately 1.5kb in size.

FOX transcription factors are expressed during development and are associated with a number of cellular and developmental differentiation processes. FOXC2 is required during early development of the kidneys, including differentiation of podocytes and maturation of the glomerular basement membrane. It is also involved in the early development of the heart.

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