Glomerular basement membrane

Glomerular basement membrane
Glomerulus; note "Glomerular basement membrane and podocytes".
Scheme of filtration barrier (blood-urine) in the kidney. A. The endothelial cells of the glomerulus; 1. pore (fenestra). B. Glomerular basement membrane: 1. lamina rara interna 2. lamina densa 3. lamina rara externa C. Podocytes: 1. enzymatic and structural protein 2. filtration slit 3. diaphragm
Identifiers
MeSH	glomerular+basement+membrane
Dorlands /Elsevier	m_08/12522684
FMA	74274
Anatomical terminology []

The glomerular basement membrane (GBM) of the kidney is the basal lamina layer of the glomerulus. The glomerular capillary endothelial cells, the GBM and the filtration slits between the podocytes perform the filtration function of the glomerulus, separating the blood in the capillaries from the filtrate that forms in Bowman's capsule. The GBM is a fusion of the endothelial cell and podocyte basal laminas.

The GBM contains three layers:

The glomerular membrane consists of mesangial cells, modified pericytes that in other parts of the body separate capillaries from each other. The podocytes adjoining them have filtration slits of diameter 25 nm that are formed by the pseudopodia arising from them. The filtration slits are covered by a diaphragm that includes the transmembrane protein nephrin.

Renal corpuscle. GBM is #1.