FLII

FLII
Identifiers
Aliases	FLII, FLI, FLIL, Fli1, actin remodeling protein
External IDs	MGI: 1342286 HomoloGene: 11092 GeneCards: FLII
Gene ontology Molecular function • actin binding • protein binding • actin filament binding Cellular component • cell junction • cytoskeleton • brush border • nucleus • focal adhesion • nucleoplasm • microtubule organizing center • cytoplasm • cytosol Biological process • multicellular organism development • actin filament severing • regulation of transcription, DNA-templated • actin cytoskeleton organization • transcription, DNA-templated Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2314	14248
Ensembl	ENSG00000177731 ENSG00000284571	ENSMUSG00000002812
UniProt	Q13045	Q9JJ28
RefSeq (mRNA)	NM_001256264 NM_001256265 NM_002018	NM_022009 NM_001302207
RefSeq (protein)	NP_001243193 NP_001243194 NP_002009	NP_001289136 NP_071292
Location (UCSC)	Chr 17: 18.24 – 18.26 Mb	Chr 11: 60.71 – 60.73 Mb
PubMed search

2314

14248

ENSG00000177731
ENSG00000284571

ENSMUSG00000002812

Q13045

Q9JJ28

NM_001256264
NM_001256265
NM_002018

NM_022009
NM_001302207

NP_001243193
NP_001243194
NP_002009

NP_001289136
NP_071292

Protein flightless-1 homolog is a protein that in humans is encoded by the FLII gene.

This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17.

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