Gelsolin

crystal structure of the copii coat subunit, sec24, complexed with a peptide from the snare protein sed5 (yeast syntaxin-5)

Identifiers

Symbol

Gelsolin

Pfam clan

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

GSN

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1C0F, 1C0G, 1D4X, 1DEJ, 1EQY, 1ESV, 1H1V, 1KCQ, 1MDU, 1NLV, 1NM1, 1NMD, 1P8X, 1P8Z, 1SOL, 1T44, 1YAG, 1YVN, 2FF3, 2FF6, 2FH1, 2FH2, 2FH3, 2FH4, 3A5L, 3A5M, 3A5N, 3A5O, 3CI5, 3CIP, 3CJB, 3CJC, 3FFK, 3FFN, 3TU5, 4PKG, 4PKH, 4PKI, 4S10, 4Z94

Identifiers

Aliases

GSN, Gsn, ADF, AGEL, gelsolin

External IDs

MGI: 95851 HomoloGene: 147 GeneCards: GSN

Gene ontology
Molecular function	• protein domain specific binding • metal ion binding • protein binding • actin binding • myosin II binding • calcium ion binding
Cellular component	• cytoplasm • cytosol • blood microparticle • plasma membrane • extracellular region • sarcoplasm • cortical actin cytoskeleton • actin cap • podosome • extracellular exosome • cytoskeleton • nucleus • secretory granule lumen • ficolin-1-rich granule lumen • ruffle • extracellular space • focal adhesion • actin cytoskeleton • lamellipodium • myelin sheath • protein complex • perinuclear region of cytoplasm
Biological process	• regulation of plasma membrane raft polarization • cellular protein metabolic process • cilium morphogenesis • sequestering of actin monomers • actin filament reorganization • amyloid fibril formation • regulation of wound healing, spreading of epidermal cells • positive regulation of keratinocyte apoptotic process • negative regulation of viral entry into host cell • striated muscle atrophy • regulation of establishment of T cell polarity • extracellular matrix disassembly • positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway • positive regulation of actin nucleation • regulation of receptor clustering • positive regulation of gene expression • cell projection organization • protein destabilization • actin filament capping • regulation of podosome assembly • renal protein absorption • hepatocyte apoptotic process • neutrophil degranulation • actin nucleation • actin filament severing • barbed-end actin filament capping • phagocytosis, engulfment • apoptotic process • aging • actin polymerization or depolymerization • oligodendrocyte development • vesicle-mediated transport • actin filament polymerization • regulation of cell adhesion • wound healing • tissue regeneration • response to ethanol • phosphatidylinositol-mediated signaling • response to folic acid • cellular response to cadmium ion • positive regulation of protein processing in phagocytic vesicle
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


2934


227753

Ensembl


ENSG00000148180


ENSMUSG00000026879

UniProt


P06396 Q5T0I1


P13020

RefSeq (mRNA)

NM_000177 NM_001127662 NM_001127663 NM_001127664 NM_001127665
NM_001127666 NM_001127667 NM_001258029 NM_001258030 NM_198252


NM_001206367 NM_001206368 NM_001206369 NM_146120

RefSeq (protein)

NP_000168 NP_001121134 NP_001121135 NP_001121136 NP_001121137
NP_001121138 NP_001121139 NP_001244958 NP_001244959 NP_937895


NP_666232.2 NP_001193296 NP_001193297 NP_001193298 NP_666232

Location (UCSC)

Chr 9: 121.21 – 121.33 Mb

Chr 2: 35.26 – 35.31 Mb

PubMed search

1C0F, 1C0G, 1D4X, 1DEJ, 1EQY, 1ESV, 1H1V, 1KCQ, 1MDU, 1NLV, 1NM1, 1NMD, 1P8X, 1P8Z, 1SOL, 1T44, 1YAG, 1YVN, 2FF3, 2FF6, 2FH1, 2FH2, 2FH3, 2FH4, 3A5L, 3A5M, 3A5N, 3A5O, 3CI5, 3CIP, 3CJB, 3CJC, 3FFK, 3FFN, 3TU5, 4PKG, 4PKH, 4PKI, 4S10, 4Z94

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