FGR (gene)

FGR
Identifiers
Aliases	FGR, SRC2, c-fgr, c-src2, p55-Fgr, p55c-fgr, p58-Fgr, p58c-fgr, FGR proto-oncogene, Src family tyrosine kinase
External IDs	MGI: 95527 HomoloGene: 3842 GeneCards: FGR
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • immunoglobulin receptor binding • kinase activity • protein binding • Fc-gamma receptor I complex binding • ATP binding • protein kinase binding • protein tyrosine kinase activity • non-membrane spanning protein tyrosine kinase activity • phosphotyrosine residue binding Cellular component • cytoplasm • cytosol • cell projection • membrane • extrinsic component of cytoplasmic side of plasma membrane • mitochondrial intermembrane space • ruffle membrane • mitochondrion • actin cytoskeleton • mitochondrial inner membrane • extracellular exosome • cytoskeleton • extracellular region • plasma membrane • aggresome • secretory granule lumen Biological process • cell differentiation • regulation of innate immune response • Fc-gamma receptor signaling pathway involved in phagocytosis • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • immune system process • positive regulation of cell migration • positive regulation of cytokine secretion • response to virus • positive regulation of mast cell degranulation • immune response-regulating cell surface receptor signaling pathway • positive regulation of phosphatidylinositol 3-kinase activity • protein phosphorylation • regulation of cell proliferation • regulation of cell shape • peptidyl-tyrosine autophosphorylation • integrin-mediated signaling pathway • protein autophosphorylation • positive regulation of phosphatidylinositol 3-kinase signaling • peptidyl-tyrosine phosphorylation • regulation of protein kinase activity • regulation of phagocytosis • defense response to Gram-positive bacterium • cell migration • innate immune response • neutrophil degranulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2268	14191
Ensembl	ENSG00000000938	ENSMUSG00000028874
UniProt	P09769	P14234
RefSeq (mRNA)	NM_001042729 NM_001042747 NM_005248	NM_010208
RefSeq (protein)	NP_001036194 NP_001036212 NP_005239	NP_034338
Location (UCSC)	Chr 1: 27.61 – 27.64 Mb	Chr 4: 132.97 – 133 Mb
PubMed search

2268

14191

ENSG00000000938

ENSMUSG00000028874

P09769

P14234

NM_001042729
NM_001042747
NM_005248

NM_010208

NP_001036194
NP_001036212
NP_005239

NP_034338

Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, also known as FGR, is a protein which in humans is encoded by the FGR gene.

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristoylation and palmitoylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.

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