FGFR1

FGFR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AGW, 1CVS, 1EVT, 1FGI, 1FGK, 1FQ9, 1XR0, 2CR3, 2FGI, 3C4F, 3DPK, 3GQI, 3GQL, 3JS2, 3KRJ, 3KRL, 3KXX, 3KY2, 3RHX, 3TT0, 4F63, 4F64, 4F65, 4NK9, 4NKA, 4NKS, 4RWI, 4RWJ, 4RWK, 4RWL, 4UWY, 4WUN, 5AM6, 5AM7, 4ZSA, 5A4C, 4UWB, 4UWC, 5A46, 5FLF, 5EW8, 5B7V
Identifiers
Aliases	FGFR1, BFGFR, CD331, CEK, FGFBR, FGFR-1, FLG, FLT-2, FLT2, HBGFR, HH2, HRTFDS, KAL2, N-SAM, OGD, bFGF-R-1, ECCL, fibroblast growth factor receptor 1
External IDs	OMIM: 136350 MGI: 95522 HomoloGene: 69065 GeneCards: FGFR1
Targeted by Drug
nintedanib, pazopanib, sorafenib, sunitinib
Gene ontology Molecular function • kinase activity • transmembrane receptor protein tyrosine kinase activity • ATP binding • protein kinase activity • transferase activity • protein homodimerization activity • protein binding • nucleotide binding • identical protein binding • fibroblast growth factor binding • fibroblast growth factor-activated receptor activity • heparin binding • Ras guanyl-nucleotide exchange factor activity • 1-phosphatidylinositol-3-kinase activity • protein tyrosine kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • receptor-receptor interaction Cellular component • cytoplasm • cytosol • membrane • extracellular region • nucleus • receptor complex • integral component of plasma membrane • cytoplasmic vesicle • plasma membrane • integral component of membrane • nucleolus Biological process • skeletal system development • ureteric bud development • fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development • positive regulation of endothelial cell chemotaxis to fibroblast growth factor • positive regulation of MAP kinase activity • positive regulation of phospholipase C activity • regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling • positive regulation of cardiac muscle cell proliferation • mesenchymal cell differentiation • positive regulation of mesenchymal cell proliferation • angiogenesis • orbitofrontal cortex development • positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway • branching involved in salivary gland morphogenesis • regulation of transcription, DNA-templated • blood vessel morphogenesis • regulation of extrinsic apoptotic signaling pathway in absence of ligand • lung development • in utero embryonic development • cell maturation • negative regulation of gene expression • transcription, DNA-templated • positive regulation of cell cycle • embryonic limb morphogenesis • positive regulation of neuron differentiation • protein autophosphorylation • auditory receptor cell development • positive regulation of MAPK cascade • paraxial mesoderm development • chondrocyte differentiation • organ induction • phosphorylation • ventricular zone neuroblast division • skeletal system morphogenesis • neuron migration • outer ear morphogenesis • negative regulation of transcription from RNA polymerase II promoter • middle ear morphogenesis • regulation of gene expression • phosphatidylinositol-mediated signaling • midbrain development • chordate embryonic development • sensory perception of sound • salivary gland morphogenesis • generation of neurons • MAPK cascade • regulation of lateral mesodermal cell fate specification • positive regulation of phospholipase activity • brain development • regulation of cell proliferation • inner ear morphogenesis • positive regulation of neuron projection development • regulation of cell differentiation • positive regulation of phosphatidylinositol 3-kinase signaling • peptidyl-tyrosine phosphorylation • lung-associated mesenchyme development • cell migration • phosphatidylinositol-3-phosphate biosynthetic process • positive regulation of GTPase activity • phosphatidylinositol phosphorylation • protein phosphorylation • fibroblast growth factor receptor signaling pathway • positive regulation of cell proliferation • regulation of phosphatidylinositol 3-kinase signaling • positive regulation of parathyroid hormone secretion • negative regulation of fibroblast growth factor production • vacuolar phosphate transport • vitamin D3 metabolic process • regulation of phosphorus metabolic process • positive regulation of mitotic cell cycle DNA replication Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2260	14182
Ensembl	ENSG00000077782	ENSMUSG00000031565
UniProt	P11362	P16092
RefSeq (mRNA)	NM_001174063 NM_001174064 NM_001174065 NM_001174066 NM_001174067 NM_015850 NM_023105 NM_023106 NM_023107 NM_023108 NM_023109 NM_023110 NM_023111 NM_032191	NM_001079908 NM_001079909 NM_010206
RefSeq (protein)	NP_001167534 NP_001167535 NP_001167536 NP_001167537 NP_001167538 NP_056934 NP_075593 NP_075594 NP_075598	NP_001073377.1 NP_001073378.1 NP_034336.2 NP_001073377 NP_001073378 NP_034336
Location (UCSC)	Chr 8: 38.41 – 38.47 Mb	Chr 8: 25.51 – 25.58 Mb
PubMed search

1AGW, 1CVS, 1EVT, 1FGI, 1FGK, 1FQ9, 1XR0, 2CR3, 2FGI, 3C4F, 3DPK, 3GQI, 3GQL, 3JS2, 3KRJ, 3KRL, 3KXX, 3KY2, 3RHX, 3TT0, 4F63, 4F64, 4F65, 4NK9, 4NKA, 4NKS, 4RWI, 4RWJ, 4RWK, 4RWL, 4UWY, 4WUN, 5AM6, 5AM7, 4ZSA, 5A4C, 4UWB, 4UWC, 5A46, 5FLF, 5EW8, 5B7V

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