FGF7

FGF7
Identifiers
Aliases	FGF7, HBGF-7, KGF, fibroblast growth factor 7
External IDs	MGI: 95521 HomoloGene: 7316 GeneCards: FGF7
Gene ontology Molecular function • heparin binding • fibroblast growth factor receptor binding • protein binding • chemoattractant activity • growth factor activity • 1-phosphatidylinositol-3-kinase activity • protein tyrosine kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • Ras guanyl-nucleotide exchange factor activity Cellular component • Golgi apparatus • extracellular region Biological process • actin cytoskeleton reorganization • mesenchymal cell proliferation • positive regulation of keratinocyte proliferation • positive regulation of epithelial cell proliferation involved in lung morphogenesis • secretion by lung epithelial cell involved in lung growth • positive regulation of epithelial cell proliferation • regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling • MAPK cascade • positive regulation of transcription, DNA-templated • fibroblast growth factor receptor signaling pathway • positive regulation of keratinocyte migration • protein localization to cell surface • response to wounding • positive regulation of cell proliferation • epidermis development • positive regulation of peptidyl-tyrosine phosphorylation • hair follicle morphogenesis • positive chemotaxis • positive regulation of cell division • phosphatidylinositol-mediated signaling • signal transduction • branching involved in salivary gland morphogenesis • regulation of phosphatidylinositol 3-kinase signaling • phosphatidylinositol phosphorylation • peptidyl-tyrosine phosphorylation • phosphatidylinositol-3-phosphate biosynthetic process • positive regulation of GTPase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2252	14178
Ensembl	ENSG00000140285	ENSMUSG00000027208
UniProt	P21781	P36363
RefSeq (mRNA)	NM_002009	NM_008008
RefSeq (protein)	NP_002000	NP_032034.1 NP_032034
Location (UCSC)	Chr 15: 49.42 – 49.49 Mb	Chr 2: 126.03 – 126.09 Mb
PubMed search

2252

14178

ENSG00000140285

ENSMUSG00000027208

P21781

P36363

NM_002009

NM_008008

NP_002000

NP_032034.1
NP_032034

Keratinocyte growth factor is a protein that in humans is encoded by the FGF7 gene.

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.

FGF7 has been shown to interact with Perlecan.

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