FGF19

FGF19
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1PWA, 2P23
Identifiers
Aliases	FGF19
External IDs	MGI: 1096383 HomoloGene: 3754 GeneCards: FGF19
Gene ontology Molecular function • fibroblast growth factor receptor binding • protein binding • growth factor activity • Ras guanyl-nucleotide exchange factor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • 1-phosphatidylinositol-3-kinase activity Cellular component • extracellular region • intracellular Biological process • positive regulation of glucose import • positive regulation of protein phosphorylation • positive regulation of JNK cascade • negative regulation of gene expression • nervous system development • MAPK cascade • fibroblast growth factor receptor signaling pathway • heart development • negative regulation of bile acid biosynthetic process • neural crest cell migration • positive regulation of cell proliferation • positive regulation of ERK1 and ERK2 cascade • phosphatidylinositol-mediated signaling • positive regulation of GTPase activity • phosphatidylinositol phosphorylation • regulation of phosphatidylinositol 3-kinase signaling • phosphatidylinositol-3-phosphate biosynthetic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9965	14170
Ensembl	ENSG00000162344	ENSMUSG00000031073
UniProt	O95750	O35622
RefSeq (mRNA)	NM_005117	NM_008003
RefSeq (protein)	NP_005108	NP_032029.1 NP_032029
Location (UCSC)	Chr 11: 69.7 – 69.7 Mb	Chr 7: 144.9 – 144.9 Mb
PubMed search

1PWA, 2P23

9965

14170

ENSG00000162344

ENSMUSG00000031073

O95750

O35622

NM_005117

NM_008003

NP_005108

NP_032029.1
NP_032029

Fibroblast growth factor 19 is a protein that in humans is encoded by the FGF19 gene. It functions as a hormone, regulating bile acid synthesis, with effects on glucose and lipid metabolism. Reduced synthesis, and blood levels, may be a factor in chronic bile acid diarrhea and in certain metabolic disorders.

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development.

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Wikipedia