FGF10

FGF10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1NUN
Identifiers
Aliases	FGF10
External IDs	MGI: 1099809 HomoloGene: 3284 GeneCards: FGF10
Genetically Related Diseases
prostate cancer
Gene ontology Molecular function • heparin binding • type 2 fibroblast growth factor receptor binding • growth factor activity • protein binding • fibroblast growth factor receptor binding • chemoattractant activity • protein tyrosine kinase activity • 1-phosphatidylinositol-3-kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • Ras guanyl-nucleotide exchange factor activity Cellular component • extracellular region • nucleus • cell surface • extracellular matrix • plasma membrane • extracellular space Biological process • positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle • bud outgrowth involved in lung branching • limb bud formation • organ growth • semicircular canal morphogenesis • embryonic pattern specification • bud elongation involved in lung branching • positive regulation of canonical Wnt signaling pathway • muscle cell fate commitment • tear secretion • positive regulation of Ras protein signal transduction • positive regulation of urothelial cell proliferation • regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling • limb development • radial glial cell differentiation • female genitalia morphogenesis • mesonephros development • odontogenesis of dentin-containing tooth • prostatic bud formation • negative regulation of cell cycle arrest • blood vessel remodeling • regulation of saliva secretion • angiogenesis • establishment of mitotic spindle orientation • positive regulation of ERK1 and ERK2 cascade • embryonic digestive tract morphogenesis • animal organ morphogenesis • hair follicle morphogenesis • metanephros development • lung saccule development • lung epithelium development • positive regulation of Notch signaling pathway • negative regulation of cell proliferation • branch elongation involved in salivary gland morphogenesis • branching involved in salivary gland morphogenesis • positive regulation of white fat cell proliferation • bronchiole morphogenesis • limb morphogenesis • blood vessel morphogenesis • lung development • thymus development • positive regulation of fibroblast proliferation • negative regulation of cell differentiation • ERK1 and ERK2 cascade • positive regulation of epithelial cell migration • positive regulation of mitotic cell cycle • spleen development • smooth muscle cell differentiation • positive regulation of transcription, DNA-templated • positive regulation of Wnt signaling pathway • Harderian gland development • protein localization to cell surface • respiratory system development • epidermis development • positive regulation of peptidyl-tyrosine phosphorylation • metanephros morphogenesis • pancreas development • mammary gland bud formation • positive chemotaxis • mesenchymal-epithelial cell signaling involved in lung development • positive regulation of hair follicle cell proliferation • lacrimal gland development • positive regulation of MAPK cascade • cell differentiation • positive regulation of keratinocyte proliferation • positive regulation of ATPase activity • positive regulation of epithelial cell proliferation involved in wound healing • epithelial cell differentiation • organ induction • positive regulation of epithelial cell proliferation • epidermis morphogenesis • wound healing • epithelial cell proliferation • regulation of activin receptor signaling pathway • positive regulation of DNA replication • chemotaxis • embryonic genitalia morphogenesis • salivary gland development • positive regulation of keratinocyte migration • response to lipopolysaccharide • thyroid gland development • keratinocyte proliferation • semicircular canal fusion • activation of MAPK activity • mammary gland specification • epithelial cell migration • white fat cell differentiation • regulation of gene expression • lung alveolus development • branching morphogenesis of an epithelial tube • embryonic digestive tract development • lung proximal/distal axis specification • phosphatidylinositol-mediated signaling • fibroblast growth factor receptor signaling pathway involved in mammary gland specification • actin cytoskeleton reorganization • positive regulation of vascular endothelial growth factor receptor signaling pathway • pituitary gland development • response to estradiol • secretion by lung epithelial cell involved in lung growth • mesenchymal cell differentiation involved in lung development • lung morphogenesis • response to organic cyclic compound • somatic stem cell population maintenance • tissue regeneration • otic vesicle formation • epithelial cell proliferation involved in salivary gland morphogenesis • cell-cell signaling • male genitalia morphogenesis • positive regulation of DNA repair • salivary gland morphogenesis • MAPK cascade • embryonic camera-type eye development • induction of positive chemotaxis • urothelial cell proliferation • animal organ formation • fibroblast growth factor receptor signaling pathway • regulation of smoothened signaling pathway • determination of left/right symmetry • inner ear morphogenesis • positive regulation of cell proliferation • submandibular salivary gland formation • Type II pneumocyte differentiation • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • digestive tract development • regulation of epithelial cell proliferation • epithelial tube branching involved in lung morphogenesis • positive regulation of lymphocyte proliferation • positive regulation of transcription from RNA polymerase II promoter • positive regulation of GTPase activity • phosphatidylinositol phosphorylation • phosphatidylinositol-3-phosphate biosynthetic process • peptidyl-tyrosine phosphorylation • regulation of phosphatidylinositol 3-kinase signaling Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2255	14165
Ensembl	ENSG00000070193	ENSMUSG00000021732
UniProt	O15520	O35565
RefSeq (mRNA)	NM_004465	NM_008002
RefSeq (protein)	NP_004456	NP_032028.1 NP_032028
Location (UCSC)	Chr 5: 44.3 – 44.39 Mb	Chr 13: 118.67 – 118.79 Mb
PubMed search

1NUN

2255

14165

ENSG00000070193

ENSMUSG00000021732

O15520

O35565

NM_004465

NM_008002

NP_004456

NP_032028.1
NP_032028

Fibroblast growth factor 10 is a protein that in humans is encoded by the FGF10 gene.

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. Fibroblast growth factor 10 is a paracrine signaling molecule seen first in the limb bud and organogenesis development. FGF10 starts the developing of limbs and its involved in the branching of morphogenesis in multiple organs such as the lungs, skin, ear and salivary glands. During the limb development Tbx4/Tbx5 stimulate the production of FGF10 in the lateral plate mesoderm where it will create an epithelial-mesenchymal FGF signal with FGF8. This positive feedback loop will increase the amount of mesenchyme resulting in a bulge. Afterwards, FGF10 will induce the formation of apical ectodermal ridge (AER) where the foot and hands will be formed. Lung development uses the same epithelial-mesenchymal signaling from FGF10 in the foregut mesenchyme with FGFR2 in the foregut epithelium. FGF10 signaling is required for epithelial branching. Therefore, all branching morphogen organs such as the lungs, skin, ear and salivary glands required the constant expression of FGF10. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7.

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