FCER1A

FCER1A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1F2Q, 1F6A, 1J86, 1J87, 1J88, 1J89, 1RPQ, 2Y7Q
Identifiers
Aliases	FCER1A, FCE1A, FcERI, Fc fragment of IgE receptor Ia
External IDs	MGI: 95494 HomoloGene: 1516 GeneCards: FCER1A
Gene ontology Molecular function • IgE receptor activity • IgE binding Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • intracellular • cell surface • external side of plasma membrane Biological process • positive regulation of calcium-mediated signaling • activation of JUN kinase activity • positive regulation of mast cell degranulation • positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process • cell surface receptor signaling pathway • activation of MAPK activity • positive regulation of type I hypersensitivity • serotonin secretion • positive regulation of peptidyl-tyrosine phosphorylation • leukotriene biosynthetic process • positive regulation of interleukin-3 biosynthetic process • signal transduction • Fc-epsilon receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2205	14125
Ensembl	ENSG00000179639	ENSMUSG00000005339
UniProt	P12319	P20489
RefSeq (mRNA)	NM_002001	NM_010184
RefSeq (protein)	NP_001992	NP_034314.2 NP_034314
Location (UCSC)	Chr 1: 159.29 – 159.31 Mb	Chr 1: 173.22 – 173.23 Mb
PubMed search

1F2Q, 1F6A, 1J86, 1J87, 1J88, 1J89, 1RPQ, 2Y7Q

2205

14125

ENSG00000179639

ENSMUSG00000005339

P12319

P20489

NM_002001

NM_010184

NP_001992

NP_034314.2
NP_034314

Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide, also known as FCER1A, is a protein which in humans is encoded by the FCER1A gene.

The high affinity IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes—potent effectors of the hypersensitivity response. The IgE receptor consists of 3 subunits: alpha (this protein), beta, and gamma; only the alpha subunit is glycosylated.

...
Wikipedia