FADS2

FADS2
Identifiers
Aliases	FADS2, D6D, DES6, FADSD6, LLCDL2, SLL0262, TU13, fatty acid desaturase 2
External IDs	MGI: 1930079 HomoloGene: 3149 GeneCards: FADS2
Gene location (Human) Chr. Chromosome 11 (human) Band 11q12.2 Start 61,792,980 bp End 61,867,354 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band n/a Start 10,064,164 bp End 10,101,503 bp
Gene ontology Molecular function • stearoyl-CoA 9-desaturase activity • oxidoreductase activity • linoleoyl-CoA desaturase activity Cellular component • integral component of membrane • integral component of plasma membrane • endoplasmic reticulum membrane • membrane • endoplasmic reticulum Biological process • unsaturated fatty acid biosynthetic process • alpha-linolenic acid metabolic process • linoleic acid metabolic process • fatty acid biosynthetic process • oxidation-reduction process • lipid metabolic process • fatty acid metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9415	56473
Ensembl	ENSG00000134824	ENSMUSG00000024665
UniProt	O95864	Q9Z0R9
RefSeq (mRNA)	NM_001281501 NM_001281502 NM_004265	NM_019699
RefSeq (protein)	NP_001268430 NP_001268431 NP_004256	NP_062673
Location (UCSC)	Chr 11: 61.79 – 61.87 Mb	Chr 11: 10.06 – 10.1 Mb
PubMed search

9415

56473

ENSG00000134824

ENSMUSG00000024665

O95864

Q9Z0R9

NM_001281501
NM_001281502
NM_004265

NM_019699

NP_001268430
NP_001268431
NP_004256

NP_062673

This article is about the gene, for main associated enzyme see D6D.

Fatty acid desaturase 2 (FADS2) is encoded by the FADS2 gene, the associated enzyme is sometimes known as FADS2 as well. Its main associated enzyme is Delta 6 desaturase (D6D) however the human enzyme been shown to also catalyze some delta-8 and delta-4 desaturases in spite of naming conventions.

Fatty acid desaturase 2 is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes cause desaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal -like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization.

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Wikipedia