FADS1

FADS1
Identifiers
Aliases	FADS1, D5D, FADS6, FADSD5, LLCDL1, TU12, fatty acid desaturase 1
External IDs	MGI: 1923517 HomoloGene: 22753 GeneCards: FADS1
Gene location (Human) Chr. Chromosome 11 (human) Band 11q12.2 Start 61,799,625 bp End 61,829,318 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band n/a Start 10,182,888 bp End 10,196,870 bp
Gene ontology Molecular function • C-5 sterol desaturase activity • oxidoreductase activity • omega-6 fatty acid desaturase activity Cellular component • integral component of membrane • endoplasmic reticulum membrane • membrane • intracellular membrane-bounded organelle • mitochondrion • endoplasmic reticulum Biological process • linoleic acid metabolic process • regulation of transcription, DNA-templated • lipid metabolic process • cellular response to starvation • cell-cell signaling • alpha-linolenic acid metabolic process • fatty acid metabolic process • icosanoid biosynthetic process • fatty acid biosynthetic process • phospholipid biosynthetic process • unsaturated fatty acid biosynthetic process • regulation of cell differentiation • oxidation-reduction process • regulation of lipid metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3992	76267
Ensembl	ENSG00000149485	ENSMUSG00000010663
UniProt	O60427	Q920L1
RefSeq (mRNA)	NM_013402	NM_146094
RefSeq (protein)	NP_037534	NP_666206
Location (UCSC)	Chr 11: 61.8 – 61.83 Mb	Chr 11: 10.18 – 10.2 Mb
PubMed search

3992

76267

ENSG00000149485

ENSMUSG00000010663

O60427

Q920L1

NM_013402

NM_146094

NP_037534

NP_666206

Fatty acid desaturase 1 is an enzyme that in humans is encoded by the FADS1 gene.

The protein encoded by the FADS1 gene is a member of the fatty acid desaturase (FADS) gene family and desaturates omega-3 and omega-6 polyunsaturated fatty acids at the delta-5 position, catalyzing the final step in the formation of eicosapentaenoic acid (EPA) and Arachidonic acid. Desaturase enzymes (such as those encoded by FADS1) regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal -like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization.

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Wikipedia