FAAH

Identifiers

FAAH, fatty acid amide hydrolase, FAAH-1, PSAB

External IDs

MGI: 109609 HomoloGene: 68184 GeneCards: FAAH

Targeted by Drug

Gene ontology
Molecular function	• protein binding • hydrolase activity • acylglycerol lipase activity • anandamide amidohydrolase activity • fatty acid amide hydrolase activity • amidase activity • oleamide hydrolase activity
Cellular component	• cytoplasm • organelle membrane • integral component of membrane • cytoskeleton • endoplasmic reticulum membrane • endomembrane system • membrane
Biological process	• arachidonic acid metabolic process • fatty acid catabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


2166


14073

Ensembl


ENSG00000117480


ENSMUSG00000034171

UniProt


O00519


O08914

RefSeq (mRNA)


NM_001441


NM_010173

RefSeq (protein)


NP_001432


NP_034303.3 NP_034303

Location (UCSC)

Chr 1: 46.39 – 46.41 Mb

Chr 4: 115.97 – 116.02 Mb

PubMed search

NP_034303.3
NP_034303

Fatty acid amide hydrolase or FAAH (EC 3.5.1.99, oleamide hydrolase, anandamide amidohydrolase) is a member of the serine hydrolase family of enzymes. It was first shown to break down anandamide in 1993. In humans, it is encoded by the gene FAAH.

FAAH is an integral membrane hydrolase with a single N-terminal transmembrane domain. In vitro, FAAH has esterase and amidase activity.In vivo, FAAH is the principal catabolic enzyme for a class of bioactive lipids called the fatty acid amides (FAAs). Members of the FAAs include:

FAAH knockout mice display highly elevated (>15-fold) levels of N-acylethanolamines and N-acyltaurines in various tissues. Because of their significantly elevated anandamide levels, FAAH KOs have an analgesic phenotype, showing reduced pain sensation in the hot plate test, the formalin test, and the tail flick test. Finally, because of their impaired ability to degrade anandamide, FAAH KOs also display supersensitivity to exogenous anandamide, a cannabinoid receptor (CB) agonist.

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Wikipedia