Ethoheptazine

Ethoheptazine

Clinical data
Trade names	Equagesic
Routes of administration	Oral
ATC code	none
Legal status
Legal status	US: Schedule IV (Some preparations)
Identifiers
IUPAC name Ethyl 1-methyl-4-phenylazepane-4-carboxylate
Synonyms	Zactane
CAS Number	77-15-6 N
PubChem (CID)	6469
DrugBank	DB08988 N
ChemSpider	6225 Y
UNII	3A4G3A848U Y
ChEMBL	CHEMBL170797 N
ECHA InfoCard	100.000.917
Chemical and physical data
Formula	C16H23NO2
Molar mass	261.36 g/mol
3D model (Jmol)	Interactive image
SMILES O=C(OCC)C2(c1ccccc1)CCN(C)CCC2
InChI InChI=1S/C16H23NO2/c1-3-19-15(18)16(14-8-5-4-6-9-14)10-7-12-17(2)13-11-16/h4-6,8-9H,3,7,10-13H2,1-2H3 Y Key:WGJHHMKQBWSQIY-UHFFFAOYSA-N Y
NY (what is this?)

Ethoheptazine (trade name Zactane) is an opioid analgesic from the phenazepane family. It was invented in the 1950s and is related to other drugs such as proheptazine and pethidine.

Ethoheptazine produces similar effects to other opioids, including analgesia, sedation, dizziness and nausea. It was sold by itself as Zactane, and is still available as a combination product with acetylsalicylic acid and meprobamate as Equagesic, which is used for the treatment of conditions where both pain and anxiety are present. It was also investigated for use as an antitussive.

Its no longer sold in the United States however it may be sold again if the law is changed to remove the drug from the CSD. Ethoheptazine is not listed as a controlled substance under the Controlled Substances Act 1970 in the United States. The controlled status (Schedule IV) of Equagesic was due to the meprobamate content. Regulation elsewhere varies. The Canadian Controlled Drugs & Substances act specifically excludes the phenazepine opioids, including proheptazine, from control.