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Acetylsalicylic acid

Aspirin
INN: acetylsalicylic acid
Aspirin-skeletal.svg
Aspirin-B-3D-balls.png
Clinical data
Pronunciation acetylsalicylic acid /əˌstəlˌsælˈsɪlk/
AHFS/Drugs.com Monograph
MedlinePlus a682878
License data
Pregnancy
category
  • AU: C
  • US: C (Risk not ruled out) D in the 3rd trimester
Routes of
administration
by mouth, rectal, lysine acetylsalicylate may be given intravenously or intramuscularly
ATC code
Legal status
Legal status
  • AU: S2 (Pharmacy only) except when given intravenously (in which case it is schedule 4), used in animal medicine (schedule 5/6) or when the dose is higher than usual.
  • UK: General sales list (GSL, OTC)
  • US: OTC
Pharmacokinetic data
Bioavailability 80–100%
Protein binding 80–90%
Metabolism Liver, (CYP2C19 and possibly CYP3A), some is also hydrolysed to salicylate in the gut wall.
Biological half-life Dose-dependent; 2 h to 3 h for low doses, 15 h to 30 h for large doses.
Excretion Urine (80–100%), sweat, saliva, feces
Identifiers
Synonyms 2-acetoxybenzoic acid
acetylsalicylate
acetylsalicylic acid
O-acetylsalicylic acid
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB ligand
ECHA InfoCard 100.000.059
Chemical and physical data
Formula C9H8O4
Molar mass 180.157 g/mol
3D model (Jmol)
Density 1.40 g/cm3
Melting point 135 °C (275 °F)
Boiling point 140 °C (284 °F) (decomposes)
Solubility in water 3 mg/mL (20 °C)
  

Aspirin, also known as acetylsalicylic acid (ASA), is a medication used to treat pain, fever, and inflammation. Specific inflammatory conditions in which it is used include Kawasaki disease, pericarditis, and rheumatic fever. Aspirin given shortly after a heart attack decreases the risk of death. Aspirin is also used long-term to help prevent heart attacks, strokes, and blood clots, in people at high risk. Aspirin may also decrease the risk of certain types of cancer, particularly colorectal cancer. For pain or fever, effects typically begin within 30 minutes. Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) and works similar to other NSAIDs but it is also an antiplatelet and suppresses the normal functioning of platelets.

Common side effects include an upset stomach. More significant side effects include stomach ulcers, stomach bleeding, and worsening asthma. Bleeding risk is greater among those who are older, drink alcohol, take other NSAIDs, or are on blood thinners. Aspirin is not recommended in the last part of pregnancy. It is not generally recommended in children with infections because of the risk of Reye's syndrome. High doses may result in ringing in the ears.


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Wikipedia

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