Erythropoietin receptor
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| Aliases | EPOR, EPO-R, erythropoietin receptor | ||||||||||||||
| External IDs | OMIM: 133171 MGI: 95408 HomoloGene: 95 GeneCards: EPOR | ||||||||||||||
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| Location (UCSC) | Chr 19: 11.38 – 11.38 Mb | Chr 9: 21.96 – 21.96 Mb | |||||||||||||
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1CN4, 1EBA, 1EBP, 1EER, 1ERN, 2JIX, 2MV6, 4Y5V, 4Y5X, 4Y5Y
The erythropoietin receptor (EpoR) is a protein that in humans is encoded by the EPOR gene. EpoR is a 52kDa peptide with a single carbohydrate chain resulting in a n approximately 56-57 kDa protein found on the surface of EPO responding cells. It is a member of the cytokine receptor family. EpoR pre-exists as dimers which upon binding of a 30 kDa ligand erythropoietin (Epo), changes its homodimerized state. These conformational changes result in the autophosphorylation of Jak2 kinases that are pre-associated with the receptor (i.e., EpoR does not possess intrinsic kinase activity and depends on Jak2 activity). At present, the most well-established function of EpoR is to promote proliferation and rescue of erythroid (red blood cell) progenitors from apoptosis.
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Wikipedia