ErbB-4

ERBB4

Protein ERBB4 PDB 2ahx.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2AHX, 2L2T, 2LCX, 2R4B, 3BBT, 3BBW, 3BCE, 3U2P, 3U7U, 3U9U

Identifiers

ERBB4, ALS19, HER4, p180erbB4, erb-b2 receptor tyrosine kinase 4

External IDs

MGI: 104771 HomoloGene: 21084 GeneCards: ERBB4

Gene location (Human)

Chr.	Chromosome 2 (human)

Band	2q34	Start	211,375,717 bp
Band	2q34	End	212,538,841 bp

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)

Band	1 C3\|1 33.8 cM	Start	68,032,186 bp
Band	1 C3\|1 33.8 cM	End	69,108,059 bp

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• transferase activity • nucleotide binding • protein kinase activity • signal transducer, downstream of receptor, with protein tyrosine kinase activity • protein homodimerization activity • epidermal growth factor receptor binding • kinase activity • protein binding • transmembrane receptor protein tyrosine kinase activity • transcription regulatory region DNA binding • ATP binding • protein tyrosine kinase activity • Ras guanyl-nucleotide exchange factor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Cellular component	• integral component of membrane • cytosol • membrane • receptor complex • plasma membrane • nucleoplasm • extracellular region • mitochondrial matrix • basolateral plasma membrane • mitochondrion • nucleus
Biological process	• mitochondrial fragmentation involved in apoptotic process • negative regulation of neuron migration • cell fate commitment • positive regulation of protein phosphorylation • regulation of cell migration • regulation of transcription, DNA-templated • olfactory bulb interneuron differentiation • embryonic pattern specification • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • central nervous system morphogenesis • positive regulation of STAT protein import into nucleus • mammary gland alveolus development • transcription, DNA-templated • nervous system development • mammary gland epithelial cell differentiation • MAPK cascade • positive regulation of phosphatidylinositol 3-kinase activity • positive regulation of transcription, DNA-templated • multicellular organism development • heart development • protein phosphorylation • positive regulation of cardiac muscle cell proliferation • neural crest cell migration • positive regulation of ERK1 and ERK2 cascade • positive regulation of protein localization to cell surface • protein autophosphorylation • cardiac muscle tissue regeneration • positive regulation of phosphatidylinositol 3-kinase signaling • peptidyl-tyrosine phosphorylation • lactation • cell proliferation • cell migration • phosphatidylinositol-mediated signaling • signal transduction • negative regulation of cell proliferation • apoptotic process • positive regulation of GTPase activity • ERBB2 signaling pathway • phosphatidylinositol phosphorylation • peptidyl-tyrosine autophosphorylation • positive regulation of cell proliferation • regulation of phosphatidylinositol 3-kinase signaling • positive regulation of apoptotic process • regulation of cell motility • negative regulation of apoptotic process • cellular response to epidermal growth factor stimulus • negative regulation of ERBB signaling pathway • positive regulation of tyrosine phosphorylation of STAT protein • interleukin-7-mediated signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


2066


13869


ENSG00000178568


ENSMUSG00000062209


Q15303


Q61527

RefSeq (mRNA)


NM_001042599 NM_005235


NM_010154

RefSeq (protein)


NP_001036064 NP_005226


NP_034284

Location (UCSC)

Chr 2: 211.38 – 212.54 Mb

Chr 2: 68.03 – 69.11 Mb

PubMed search

2AHX, 2L2T, 2LCX, 2R4B, 3BBT, 3BBW, 3BCE, 3U2P, 3U7U, 3U9U

ENSG00000178568

ENSMUSG00000062209

NM_001042599
NM_005235

NP_001036064
NP_005226

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Wikipedia

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