EpCAM

EPCAM
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4MZV
Identifiers
Aliases	EPCAM, DIAR5, EGP-2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, M4S1, MIC18, MK-1, TACSTD1, TROP1, epithelial cell adhesion molecule
External IDs	MGI: 106653 HomoloGene: 1764 GeneCards: EPCAM
Gene ontology Molecular function • protein complex binding • protein binding • cadherin binding involved in cell-cell adhesion Cellular component • integral component of membrane • lateral plasma membrane • membrane • bicellular tight junction • plasma membrane • cell surface • cell junction • basolateral plasma membrane • apical plasma membrane • extracellular exosome • integral component of plasma membrane Biological process • ureteric bud development • positive regulation of cell motility • negative regulation of cell-cell adhesion mediated by cadherin • signal transduction involved in regulation of gene expression • negative regulation of apoptotic process • stem cell differentiation • positive regulation of cell proliferation • positive regulation of stem cell proliferation • positive regulation of transcription from RNA polymerase II promoter • leukocyte migration • cell-cell adhesion via plasma-membrane adhesion molecules Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4072	17075
Ensembl	ENSG00000119888	ENSMUSG00000045394
UniProt	P16422	Q99JW5
RefSeq (mRNA)	NM_002354	NM_008532
RefSeq (protein)	NP_002345	NP_032558.2 NP_032558
Location (UCSC)	Chr 2: 47.35 – 47.39 Mb	Chr 17: 87.64 – 87.65 Mb
PubMed search

4MZV

4072

17075

ENSG00000119888

ENSMUSG00000045394

P16422

Q99JW5

NM_002354

NM_008532

NP_002345

NP_032558.2
NP_032558

Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein mediating Ca²⁺-independent homotypic cell–cell adhesion in epithelia. EpCAM is also involved in cell signaling, migration, proliferation, and differentiation. Additionally, EpCAM has oncogenic potential via its capacity to upregulate c-myc, e-fabp, and cyclins A & E. Since EpCAM is expressed exclusively in epithelia and epithelial-derived neoplasms, EpCAM can be used as diagnostic marker for various cancers. It appears to play a role in tumorigenesis and metastasis of carcinomas, so it can also act as a potential prognostic marker and as a potential target for immunotherapeutic strategies.

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