Endothelin receptor type A

EDNRA
Identifiers
Aliases	EDNRA, ET-A, ETA, ETA-R, ETAR, ETRA, hET-AR, MFDA, endothelin receptor type A
External IDs	MGI: 105923 HomoloGene: 1478 GeneCards: EDNRA
Genetically Related Diseases
intracranial aneurysm
Targeted by Drug
ambrisentan, atrasentan, bq-123, darusentan, macitentan, sitaxentan, zibotentan
Gene ontology Molecular function • endothelin receptor activity • G-protein coupled receptor activity • signal transducer activity • protein binding • phosphatidylinositol phospholipase C activity Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane Biological process • smooth muscle contraction • G-protein coupled receptor signaling pathway • response to hypoxia • neural crest cell development • vasoconstriction • head development • in utero embryonic development • activation of phospholipase C activity • respiratory gaseous exchange • activation of adenylate cyclase activity • regulation of blood pressure • endothelin receptor signaling pathway • enteric nervous system development • heart development • negative regulation of cAMP biosynthetic process • artery smooth muscle contraction • branching involved in blood vessel morphogenesis • cell proliferation • signal transduction • glucose transport • positive regulation of cytosolic calcium ion concentration Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1909	13617
Ensembl	ENSG00000151617	ENSMUSG00000031616
UniProt	P25101	Q61614
RefSeq (mRNA)	NM_001166055 NM_001256283 NM_001957	NM_010332
RefSeq (protein)	NP_001159527 NP_001243212 NP_001948	NP_034462.1 NP_034462
Location (UCSC)	Chr 4: 147.48 – 147.54 Mb	Chr 8: 77.66 – 77.72 Mb
PubMed search

1909

13617

ENSG00000151617

ENSMUSG00000031616

P25101

Q61614

NM_001166055
NM_001256283
NM_001957

NM_010332

NP_001159527
NP_001243212
NP_001948

NP_034462.1
NP_034462

Endothelin receptor type A, also known as ET_A, is a human G protein-coupled receptor.

Endothelin receptor type A has been shown to interact with HDAC7A and HTATIP.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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