Elongation factor 2

EEF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4V6X
Identifiers
Aliases	EEF2, EEF-2, EF-2, EF2, SCA26, eukaryotic translation elongation factor 2, Eukaryotic elongation factor 2
External IDs	MGI: 95288 HomoloGene: 134867 GeneCards: EEF2
Gene ontology Molecular function • nucleotide binding • ribosome binding • GTP binding • p53 binding • translation elongation factor activity • actin filament binding • protein binding • 5S rRNA binding • protein kinase binding • RNA binding • GTPase activity • cadherin binding Cellular component • cytoplasm • polysome • membrane • plasma membrane • intracellular ribonucleoprotein complex • aggresome • membrane raft • extracellular exosome • nucleus • polysomal ribosome • extracellular matrix • extracellular region • cytosol • secretory granule lumen • ficolin-1-rich granule lumen Biological process • response to estradiol • positive regulation of cytoplasmic translation • skeletal muscle contraction • translational elongation • aging • positive regulation of translation • response to endoplasmic reticulum stress • cellular response to brain-derived neurotrophic factor stimulus • response to ischemia • hematopoietic progenitor cell differentiation • peptidyl-diphthamide biosynthetic process from peptidyl-histidine • glial cell proliferation • skeletal muscle cell differentiation • response to folic acid • response to ethanol • response to hydrogen peroxide • translation • protein methylation • response to drug • neutrophil degranulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1938	13629
Ensembl	ENSG00000167658	ENSMUSG00000034994
UniProt	P13639	P58252
RefSeq (mRNA)	NM_001961	NM_007907
RefSeq (protein)	NP_001952	NP_031933.1 NP_031933
Location (UCSC)	Chr 19: 3.98 – 3.99 Mb	Chr 10: 81.18 – 81.18 Mb
PubMed search

4V6X

1938

13629

ENSG00000167658

ENSMUSG00000034994

P13639

P58252

NM_001961

NM_007907

NP_001952

NP_031933.1
NP_031933

Eukaryotic elongation factor 2 is a protein that in humans is encoded by the EEF2 gene.

This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the ribosome. This protein is completely inactivated by EF-2 kinase phosphorylation.

It is the target of diphtheria toxin (from Corynebacterium diphtheriae), and exotoxin A (from Pseudomonas aeruginosa). The inactivation of EF-2 by toxins inhibits protein production in the host, causing symptoms due to loss of function in affected cells.

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