Elafin

PI3
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1FLE, 2REL
Identifiers
Aliases	PI3, ESI, SKALP, WAP3, WFDC14, cementoin, peptidase inhibitor 3
External IDs	HomoloGene: 122140 GeneCards: PI3
Gene location (Human) Chr. Chromosome 20 (human) Band 20q13.12 Start 45,174,876 bp End 45,176,544 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • peptidase inhibitor activity • endopeptidase inhibitor activity • serine-type endopeptidase inhibitor activity • structural constituent of epidermis Cellular component • proteinaceous extracellular matrix • extracellular exosome • extracellular region • cytosol • cornified envelope Biological process • negative regulation of peptidase activity • copulation • negative regulation of endopeptidase activity • antimicrobial humoral response • cornification • peptide cross-linking • skin epidermis development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5266	n/a
Ensembl	ENSG00000124102	n/a
UniProt	P19957	n/a
RefSeq (mRNA)	NM_002638	n/a
RefSeq (protein)	NP_002629	n/a
Location (UCSC)	Chr 20: 45.17 – 45.18 Mb	n/a
PubMed search		n/a

1FLE, 2REL

5266

n/a

ENSG00000124102

n/a

P19957

n/a

NM_002638

n/a

NP_002629

n/a

Elafin, also known as peptidase inhibitor 3 or skin-derived antileukoprotease (SKALP), is a protein that in humans is encoded by the PI3 gene.

This gene encodes an elastase-specific protease inhibitor, which contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster.

Elafin has been found to have utility in serving as a biomarker for graft versus host disease of the skin.

Elafin plays some role in gut inflammation.

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Wikipedia