Edward N. Trifonov
| Edward Nikolayevich Trifonov | |
|---|---|
 |
|
| Born |
March 31, 1937 (age 81) Leningrad, USSR |
| Residence | Haifa, Israel |
| Nationality | Israeli |
| Alma mater | Moscow Institute of Physics and Technology |
| Known for | DNA periodicity, DNA curvature, nucleosome positioning, protein structure, molecular evolution |
| Scientific career | |
| Fields | Bioinformatics, genomics, molecular biophysics, proteomics |
| Institutions |
Moscow Institute of Physics and Technology I. V. Kurchatov Institute of Atomic Energy Weizmann Institute of Science University of Haifa |
| Doctoral advisor | Yuri Semenovich Lazurkin |
| Doctoral students |
Jaime Lagunez 25 altogether |
Edward Nikolayevich Trifonov (Hebrew: אדוארד טריפונוב, Russian: Эдуapд Тpифoнoв; b. March 31, 1937) is a Russian-born Israeli molecular biophysicist and a founder of Israeli bioinformatics. In his research, he specializes in the recognition of weak signal patterns in biological sequences and is known for his unorthodox scientific methods.
He discovered the 3-bp and 10-bp periodicity in the DNA sequences, as well as the rules determining the curvature of DNA molecules and their bending within nucleosomes. Trifonov unveiled multiple novel codes in biological sequences and the modular structure of proteins. He proposed an abiogenic theory of the origin of life, and molecular evolution from single nucleotides and amino acids to present-day DNA and protein sequences.
Trifonov was born in Leningrad (now Saint Petersburg), USSR in 1937. He was raised by his mother, Riva, and his step-father, Nikolay Nikolayevich Trifonov. In his school years, he became interested in medicine and physics. As a result, he went to study biophysics in Moscow. He started his scientific career in the USSR. In 1976, he made aliyah (immigrated as a Jew) to Israel. His role model is Gregor Mendel.
Trifonov graduated in biophysics from the Moscow Institute of Physics and Technology in 1961 and earned his PhD degree in molecular biophysics there in 1970. He worked as a researcher at the Moscow Physico-Technical Institute from 1961 to 1964. Then he moved to the Biological Department at the I. V. Kurchatov Institute of Atomic Energy in Moscow, staying there until 1975. After his immigration to Israel, he joined the Department of Polymer Research at The Weizmann Institute of Science as an associate professor. He worked there from 1976 to 1991 before moving to the Department of Structural Biology as a full professor in 1992. He was appointed professor emeritus in 2003. During that time, he was also a head of the Center for Genome Structure and Evolution at the Institute of Molecular Sciences in Palo Alto, California (1992–1995).
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