ELK1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1DUX

Identifiers

External IDs

Gene ontology
Molecular function	• DNA binding • sequence-specific DNA binding • core promoter binding • RNA polymerase II transcription factor binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • chromatin binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • protein binding • double-stranded DNA binding
Cellular component	• cytoplasm • axon terminus • nucleoplasm • neuronal cell body • dendrite • mitochondrion • nucleus
Biological process	• cell differentiation • regulation of transcription, DNA-templated • response to light stimulus • cellular response to testosterone stimulus • response to fibroblast growth factor • positive regulation of neuron death • transcription, DNA-templated • positive regulation of transcription, DNA-templated • cellular response to gamma radiation • cellular response to lipid • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


2002


13712


ENSG00000126767


ENSMUSG00000009406


P19419


P41969

RefSeq (mRNA)


NM_005229 NM_001114123 NM_001257168


NM_007922

RefSeq (protein)


NP_001107595 NP_001244097 NP_005220


NP_031948.4 NP_031948

Location (UCSC)

PubMed search

ETS domain-containing protein Elk-1 is a protein that in humans is encoded by the ELK1 gene. Elk-1 functions as a transcription activator. It is classified as a ternary complex factor (TCF), a subclass of the ETS family, which is characterized by a common protein domain that regulates DNA binding to target sequences. Elk1 plays important roles in various contexts, including long-term memory formation, drug addiction, Alzheimer's disease, Down syndrome, breast cancer, and depression.