EIF4EBP3

EIF4EBP3
Identifiers
Aliases	EIF4EBP3, 4E-BP3, 4EBP3, eukaryotic translation initiation factor 4E binding protein 3
External IDs	MGI: 1270847 HomoloGene: 37841 GeneCards: EIF4EBP3
Gene ontology Molecular function • protein binding • eukaryotic initiation factor 4E binding • translation repressor activity Cellular component • cytoplasm • eukaryotic translation initiation factor 4F complex • membrane Biological process • negative regulation of translation • regulation of translation • negative regulation of translational initiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8637	108112
Ensembl	ENSG00000243056	ENSMUSG00000090264
UniProt	O60516	Q80VV3
RefSeq (mRNA)	NM_003732	NM_201256
RefSeq (protein)	NP_003723	NP_957708.1 NP_957708
Location (UCSC)	Chr 5: 140.55 – 140.55 Mb	Chr 18: 36.66 – 36.67 Mb
PubMed search

8637

108112

ENSG00000243056

ENSMUSG00000090264

O60516

Q80VV3

NM_003732

NM_201256

NP_003723

NP_957708.1
NP_957708

Eukaryotic translation initiation factor 4E-binding protein 3 is a protein that in humans is encoded by the EIF4EBP3 gene.

This gene encodes a member of the EIF4EBP family which derives it name from proteins that bind to eukaryotic initiation factor 4E and that prevent its assembly into EIF4F. Co-transcription of this gene and the neighboring upstream gene (MASK) generates a transcript (MASK-BP3) which encodes a fusion protein composed of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments.

EIF4EBP3 has been shown to interact with EIF4E.

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