EIF4A3

EIF4A3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HXY, 2HYI, 2J0Q, 2J0S, 2J0U, 2XB2, 3EX7, 4C9B
Identifiers
Aliases	EIF4A3, DDX48, MUK34, NMP265, NUK34, RCPS, eIF4AIII, eukaryotic translation initiation factor 4A3
External IDs	MGI: 1923731 HomoloGene: 5602 GeneCards: EIF4A3
Gene ontology Molecular function • nucleotide binding • ATP-dependent RNA helicase activity • selenocysteine insertion sequence binding • helicase activity • poly(A) binding • RNA stem-loop binding • protein binding • nucleic acid binding • ribonucleoprotein complex binding • hydrolase activity • ATP binding • mRNA binding • RNA binding Cellular component • cytoplasm • cytosol • nuclear speck • catalytic step 2 spliceosome • membrane • exon-exon junction complex • intracellular ribonucleoprotein complex • neuronal cell body • dendrite • spliceosomal complex • nucleus • nucleoplasm Biological process • nuclear-transcribed mRNA poly(A) tail shortening • mRNA transport • negative regulation of translation • associative learning • response to organic cyclic compound • regulation of mRNA binding • mRNA processing • positive regulation of translation • negative regulation of gene expression • negative regulation of excitatory postsynaptic potential • cellular response to brain-derived neurotrophic factor stimulus • cellular response to selenite ion • exploration behavior • RNA secondary structure unwinding • RNA splicing • transport • rRNA processing • embryonic cranial skeleton morphogenesis • negative regulation of selenocysteine insertion sequence binding • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • regulation of translation • negative regulation of selenocysteine incorporation • mRNA splicing, via spliceosome • RNA export from nucleus • termination of RNA polymerase II transcription • mRNA export from nucleus • mRNA 3'-end processing • positive regulation of transcription from RNA polymerase II promoter • positive regulation of mRNA splicing, via spliceosome Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9775	192170
Ensembl	ENSG00000141543	ENSMUSG00000025580
UniProt	P38919	Q91VC3
RefSeq (mRNA)	NM_014740	NM_138669
RefSeq (protein)	NP_055555	NP_619610.1 NP_619610
Location (UCSC)	Chr 17: 80.14 – 80.15 Mb	Chr 11: 119.29 – 119.3 Mb
PubMed search

2HXY, 2HYI, 2J0Q, 2J0S, 2J0U, 2XB2, 3EX7, 4C9B

9775

192170

ENSG00000141543

ENSMUSG00000025580

P38919

Q91VC3

NM_014740

NM_138669

NP_055555

NP_619610.1
NP_619610

Eukaryotic initiation factor 4A-III is a protein that in humans is encoded by the EIF4A3 gene.

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4A-I and eIF4A-II, two other members of the DEAD box protein family.

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