EIF2S2

EIF2S2
Identifiers
Aliases	EIF2S2, EIF2, EIF2B, EIF2beta, PPP1R67, eIF-2-beta, eukaryotic translation initiation factor 2 subunit beta
External IDs	MGI: 1914454 HomoloGene: 2904 GeneCards: EIF2S2
Gene ontology Molecular function • translation factor activity, RNA binding • protein binding • translation initiation factor activity • metal ion binding • RNA binding Cellular component • cytoplasm • cytosol • nucleus • eukaryotic translation initiation factor 2 complex Biological process • translational initiation • male germ cell proliferation • male gonad development • in utero embryonic development • transmembrane transport • translation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8894	67204
Ensembl	ENSG00000125977	ENSMUSG00000074656
UniProt	P20042	Q99L45
RefSeq (mRNA)	NM_003908 NM_001316363 NM_001316364	NM_026030
RefSeq (protein)	NP_001303292 NP_001303293 NP_003899	NP_080306
Location (UCSC)	Chr 20: 34.09 – 34.11 Mb	Chr 2: 154.87 – 154.89 Mb
PubMed search

8894

67204

ENSG00000125977

ENSMUSG00000074656

P20042

Q99L45

NM_003908
NM_001316363
NM_001316364

NM_026030

NP_001303292
NP_001303293
NP_003899

NP_080306

Eukaryotic translation initiation factor 2 subunit 2 (eIF2β) is a protein that in humans is encoded by the EIF2S2 gene.

Eukaryotic translation initiation factor 2 (eIF2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. eIF2 is composed of three subunits, alpha (α), beta (β, this article), and gamma (γ), with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the eIF2 complex for another round of initiation.

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