EIF2S1

EIF2S1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KL9, 1Q8K
Identifiers
Aliases	EIF2S1, EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A, eukaryotic translation initiation factor 2 subunit alpha
External IDs	MGI: 95299 HomoloGene: 3020 GeneCards: EIF2S1
Gene ontology Molecular function • translation initiation factor activity • ribosome binding • protein binding • nucleic acid binding • RNA binding Cellular component • cytoplasm • eukaryotic 48S preinitiation complex • polysome • cytosol • ribosome • membrane • multi-eIF complex • eukaryotic translation initiation factor 2B complex • glial limiting end-foot • translation initiation ternary complex • cytoplasmic stress granule • extracellular exosome • nucleus • eukaryotic translation initiation factor 2 complex Biological process • cellular response to heat • positive regulation of type B pancreatic cell apoptotic process • negative regulation of translational initiation in response to stress • cellular response to UV • cellular response to amino acid starvation • aging • response to endoplasmic reticulum stress • PERK-mediated unfolded protein response • response to manganese-induced endoplasmic reticulum stress • transmembrane transport • translational initiation • protein autophosphorylation • regulation of translation • regulation of translational initiation in response to stress • negative regulation of guanyl-nucleotide exchange factor activity • positive regulation of neuron death • translation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1965	13665
Ensembl	ENSG00000134001	ENSMUSG00000021116
UniProt	P05198	Q6ZWX6
RefSeq (mRNA)	NM_004094	NM_026114
RefSeq (protein)	NP_004085	NP_080390.1 NP_080390
Location (UCSC)	Chr 14: 67.36 – 67.39 Mb	Chr 12: 78.86 – 78.89 Mb
PubMed search

1KL9, 1Q8K

1965

13665

ENSG00000134001

ENSMUSG00000021116

P05198

Q6ZWX6

NM_004094

NM_026114

NP_004085

NP_080390.1
NP_080390

Eukaryotic translation initiation factor 2 subunit 1 (eIF2α) is a protein that in humans is encoded by the EIF2S1 gene.

The protein encoded by this gene is the alpha (α) subunit of the translation initiation factor eIF2 complex which catalyzes an early regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA (Met-tRNA_i^Met) to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, eIF2, and GTP. eIF2 is composed of 3 nonidentical subunits, alpha (α, 36 kD, this article), beta (β, 38 kD), and gamma (γ, 52 kD). The rate of formation of the ternary complex is modulated by the phosphorylation state of eIF2α.

...
Wikipedia