EIF2B2

EIF2B2
Identifiers
Aliases	EIF2B2, EIF-2Bbeta, EIF2B, eukaryotic translation initiation factor 2B subunit beta
External IDs	MGI: 2145118 HomoloGene: 6507 GeneCards: EIF2B2
Gene ontology Molecular function • translation initiation factor activity • guanyl-nucleotide exchange factor activity • GTP binding • protein binding • ATP binding Cellular component • cytoplasm • cytosol • eukaryotic translation initiation factor 2B complex Biological process • response to peptide hormone • response to heat • response to glucose • cellular response to stimulus • central nervous system development • cellular metabolic process • ovarian follicle development • myelination • oligodendrocyte development • regulation of translational initiation • translation • positive regulation of GTPase activity • translational initiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8892	217715
Ensembl	ENSG00000119718	ENSMUSG00000004788
UniProt	P49770	Q99LD9
RefSeq (mRNA)	NM_014239	NM_145445
RefSeq (protein)	NP_055054	NP_663420
Location (UCSC)	Chr 14: 75 – 75.01 Mb	Chr 12: 85.22 – 85.23 Mb
PubMed search

8892

217715

ENSG00000119718

ENSMUSG00000004788

P49770

Q99LD9

NM_014239

NM_145445

NP_055054

NP_663420

Translation initiation factor eIF-2B subunit beta is a protein that in humans is encoded by the EIF2B2 gene.

Eukaryotic initiation factor-2B (EIF2B) is a GTP exchange protein essential for protein synthesis. It consists of alpha (EIF2B1; MIM 606686), beta (EIF2B2), gamma (EIF2B3; MIM 606273), delta (EIF2B4; MIM 606687), and epsilon (EIF2B5; MIM 603945) subunits. EIF2B activates its EIF2 (see MIM 603907) substrate by exchanging EIF2-bound GDP for GTP.

EIF2B2 has been shown to interact with EIF2B5 and NCK1.

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Wikipedia