EFNB2

EFNB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HLE, 2I85, 2VSK, 2VSM, 2WO2, 3GXU, 4UF7
Identifiers
Aliases	EFNB2, EPLG5, HTKL, Htk-L, LERK5, ephrin B2
External IDs	MGI: 105097 HomoloGene: 3019 GeneCards: EFNB2
Gene ontology Molecular function • virus receptor activity • protein binding • receptor binding • ephrin receptor binding Cellular component • integral component of membrane • membrane • focal adhesion • plasma membrane • integral component of plasma membrane Biological process • cell differentiation • blood vessel morphogenesis • negative regulation of keratinocyte proliferation • regulation of chemotaxis • cell-cell signaling • anatomical structure morphogenesis • T cell costimulation • lymph vessel development • nervous system development • cell migration involved in sprouting angiogenesis • multicellular organism development • cell adhesion • nephric duct morphogenesis • angiogenesis • animal organ morphogenesis • viral entry into host cell • positive regulation of cardiac muscle cell differentiation • viral process • venous blood vessel morphogenesis • positive regulation of aorta morphogenesis • positive regulation of cell proliferation • ephrin receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1948	13642
Ensembl	ENSG00000125266	ENSMUSG00000001300
UniProt	P52799	P52800
RefSeq (mRNA)	NM_004093	NM_010111
RefSeq (protein)	NP_004084	NP_034241
Location (UCSC)	Chr 13: 106.49 – 106.54 Mb	Chr 8: 8.62 – 8.66 Mb
PubMed search

2HLE, 2I85, 2VSK, 2VSM, 2WO2, 3GXU, 4UF7

1948

13642

ENSG00000125266

ENSMUSG00000001300

P52799

P52800

NM_004093

NM_010111

NP_004084

NP_034241

Ephrin-B2 is a protein that in humans is encoded by the EFNB2 gene.

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors.

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Wikipedia