EFNA5

EFNA5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2X11, 3MX0, 4BK5, 4BKA, 4L0P, 4M4R
Identifiers
Aliases	EFNA5, AF1, EFL5, EPLG7, GLC1M, LERK7, RAGS, ephrin A5
External IDs	MGI: 107444 HomoloGene: 1482 GeneCards: EFNA5
Gene location (Human) Chr. Chromosome 5 (human) Band 5q21.3 Start 107,376,889 bp End 107,670,895 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 E1.1|17 32.57 cM Start 62,604,184 bp End 62,881,317 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • neurotrophin TRKC receptor binding • transmembrane receptor protein tyrosine kinase activator activity • neurotrophin TRKA receptor binding • ephrin receptor binding • chemorepellent activity • neurotrophin TRKB receptor binding • protein binding Cellular component • membrane • plasma membrane • anchored component of external side of plasma membrane • caveola • anchored component of membrane • basement membrane • adherens junction • cell periphery Biological process • positive regulation of synapse assembly • apoptotic process • cell differentiation • regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of protein phosphorylation • negative chemotaxis • regulation of actin cytoskeleton organization • regulation of GTPase activity • ephrin receptor signaling pathway • regulation of microtubule cytoskeleton organization • positive regulation of collateral sprouting • nervous system development • multicellular organism development • regulation of cell-cell adhesion • positive regulation of peptidyl-tyrosine phosphorylation • regulation of focal adhesion assembly • regulation of cell morphogenesis • collateral sprouting • negative regulation of substrate adhesion-dependent cell spreading • retinal ganglion cell axon guidance • cellular response to follicle-stimulating hormone stimulus • cellular response to forskolin • activation of transmembrane receptor protein tyrosine kinase activity • axon guidance Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1946	13640
Ensembl	ENSG00000184349	ENSMUSG00000048915
UniProt	P52803	O08543
RefSeq (mRNA)	NM_001962	NM_010109 NM_207654
RefSeq (protein)	NP_001953	NP_034239 NP_997537
Location (UCSC)	Chr 5: 107.38 – 107.67 Mb	Chr 5: 62.6 – 62.88 Mb
PubMed search

2X11, 3MX0, 4BK5, 4BKA, 4L0P, 4M4R

1946

13640

ENSG00000184349

ENSMUSG00000048915

P52803

O08543

NM_001962

NM_010109
NM_207654

NP_001953

NP_034239
NP_997537

Ephrin A5 is a protein that in humans is encoded by the EFNA5 gene.

Ephrin A5 is a glycosylphosphatidylinositol (GPI)-anchored protein of the ephrin-A subclass of ephrin ligands that binds to the EphA subclass of Eph receptors. Ephrin A5 has also been shown to bind to the EphB2 receptor.

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Wikipedia