EEA1

EEA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HYI, 1HYJ, 1JOC, 3MJH
Identifiers
Aliases	EEA1, MST105, MSTP105, ZFYVE2, early endosome antigen 1
External IDs	OMIM: 605070 MGI: 2442192 HomoloGene: 37822 GeneCards: EEA1
Gene ontology Molecular function • protein homodimerization activity • zinc ion binding • metal ion binding • calmodulin binding • GTP-dependent protein binding • 1-phosphatidylinositol binding • protein binding Cellular component • cytoplasm • recycling endosome • cytosol • endosome • early endosome membrane • membrane • axonal spine • serine-pyruvate aminotransferase complex • early endosome • extrinsic component of plasma membrane • extracellular exosome • cytoplasmic vesicle • presynapse Biological process • endocytosis • early endosome to late endosome transport • synaptic vesicle to endosome fusion • vesicle fusion • viral RNA genome replication Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8411	216238
Ensembl	ENSG00000102189	ENSMUSG00000036499
UniProt	Q15075	Q8BL66
RefSeq (mRNA)	NM_003566	NM_001001932
RefSeq (protein)	NP_003557	NP_001001932.1 NP_001001932
Location (UCSC)	Chr 12: 92.77 – 92.93 Mb	Chr 10: 95.94 – 96.05 Mb
PubMed search

1HYI, 1HYJ, 1JOC, 3MJH

8411

216238

ENSG00000102189

ENSMUSG00000036499

Q15075

Q8BL66

NM_003566

NM_001001932

NP_003557

NP_001001932.1
NP_001001932

The gene EEA1 encodes for the 1400 amino acid protein, Early Endosome Antigen 1.

EEA1 localizes exclusively to early endosomes and has an important role in endosomal trafficking. EEA1 binds directly to the phospholipid phosphatidylinositol 3-phosphate through its C-terminal FYVE domain and forms a homodimer through a coiled coil. EEA1 acts as a tethering molecule that couples vesicle docking with SNAREs such as N-ethylmaleimide sensitive fusion protein, bringing the endosomes physically closer and ultimately resulting in the fusion and delivery of endosomal cargo.

...
Wikipedia