N-ethylmaleimide sensitive fusion protein

NSF
Identifiers
Aliases	NSF, SKD2, N-ethylmaleimide sensitive factor, N-ethylmaleimide sensitive factor, vesicle fusing ATPase, SEC18
External IDs	OMIM: 601633 MGI: 104560 HomoloGene: 4502 GeneCards: NSF
Gene ontology Molecular function • ATPase activity, coupled • nucleotide binding • PDZ domain binding • syntaxin-1 binding • metal ion binding • Rab GTPase binding • protein binding • syntaxin binding • hydrolase activity • ATP binding • protein kinase binding • SNARE binding • protein complex binding • ionotropic glutamate receptor binding • ATPase activity Cellular component • postsynaptic density of dendrite • myelin sheath • plasma membrane • dendritic shaft • lysosomal membrane • extracellular exosome • Golgi membrane • cytoplasm • cytosol • Golgi stack Biological process • plasma membrane fusion • positive regulation of protein catabolic process • regulation of exocytosis • potassium ion transport • ER to Golgi vesicle-mediated transport • COPII vesicle coating • protein transport • intracellular protein transport • vesicle-mediated transport • positive regulation of receptor recycling • exocytosis • retrograde vesicle-mediated transport, Golgi to ER • SNARE complex disassembly • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4905	18195
Ensembl	ENSG00000073969 ENSG00000278174 ENSG00000276262	ENSMUSG00000034187
UniProt	P46459	P46460
RefSeq (mRNA)	NM_006178	NM_008740
RefSeq (protein)	NP_006169	NP_032766
Location (UCSC)	Chr 17: 46.59 – 46.76 Mb	Chr 11: 103.82 – 103.95 Mb
PubMed search

4905

18195

ENSG00000073969
ENSG00000278174
ENSG00000276262

ENSMUSG00000034187

P46459

P46460

NM_006178

NM_008740

NP_006169

NP_032766

N-ethylmaleimide-sensitive factor, also known as NSF or N-ethylmaleimide sensitive fusion proteins, is an enzyme which in humans is encoded by the NSF gene.

NSF is a homohexameric AAA ATPase involved in membrane fusion. NSF is ubiquitously found in the cytoplasm of eukaryotic cells. It is a central component of the cellular machinery in the transfer of membrane vesicles from one membrane compartment to another. During this process, SNARE proteins on two joining membranes (usually a vesicle and a target membrane such as the plasma membrane) form a tight complex. This aids fusion of the vesicle with the target membrane. It has been proposed that the role of NSF is to undo these SNARE complexes once membrane fusion has occurred, using the hydrolysis of ATP as an energy source, allowing the dissociated SNAREs to be recycled for reuse in further rounds of membrane fusion. This proposal remains controversial, however. Recent work indicates that the ATPase function of NSF does not function in recycling of vesicles but rather functions in the act of fusing vesicles with the plasma membrane.

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Wikipedia