E4BP4

NFIL3
Identifiers
Aliases	NFIL3, E4BP4, IL3BP1, NF-IL3A, NFIL3A, nuclear factor, interleukin 3 regulated
External IDs	MGI: 109495 HomoloGene: 3928 GeneCards: NFIL3
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II regulatory region sequence-specific DNA binding • protein binding • transcription corepressor activity • RNA polymerase II core promoter sequence-specific DNA binding Cellular component • nucleus Biological process • cellular response to interleukin-4 • positive regulation of gene expression • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • circadian rhythm • immune response • GO:0006350 transcription, DNA-templated • rhythmic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4783	18030
Ensembl	ENSG00000165030	ENSMUSG00000056749
UniProt	Q16649	O08750
RefSeq (mRNA)	NM_005384 NM_001289999 NM_001290000	NM_017373
RefSeq (protein)	NP_001276928 NP_001276929 NP_005375	NP_059069.1 NP_059069
Location (UCSC)	Chr 9: 91.41 – 91.42 Mb	Chr 13: 52.97 – 52.98 Mb
PubMed search

4783

18030

ENSG00000165030

ENSMUSG00000056749

Q16649

O08750

NM_005384
NM_001289999
NM_001290000

NM_017373

NP_001276928
NP_001276929
NP_005375

NP_059069.1
NP_059069

Nuclear factor, interleukin 3 regulated, also known as NFIL3 or E4BP4 is a protein which in humans is encoded by the NFIL3 gene.

Expression of interleukin-3 (IL3) is restricted to activated T cells, natural killer (NK) cells, and mast cell lines. Transcription initiation depends on the activating capacity of specific protein factors, such as NFIL3, that bind to regulatory regions of the gene, usually upstream of the transcription start site.

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