E2F1

E2F1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H24, 1O9K, 2AZE
Identifiers
Aliases	E2F1, E2F-1, RBAP1, RBBP3, RBP3, E2F transcription factor 1
External IDs	OMIM: 189971 MGI: 101941 HomoloGene: 3828 GeneCards: E2F1
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • core promoter binding • transcription factor activity, sequence-specific DNA binding • transcription factor binding • protein binding • transcription regulatory region DNA binding • protein kinase binding • protein dimerization activity Cellular component • cytoplasm • transcription factor complex • Rb-E2F complex • nuclear chromatin • nucleus • mitochondrion • nucleoplasm • centrosome Biological process • cellular response to nerve growth factor stimulus • negative regulation of fat cell differentiation • regulation of transcription, DNA-templated • lens fiber cell apoptotic process • negative regulation of transcription involved in G1/S transition of mitotic cell cycle • positive regulation of fibroblast proliferation • negative regulation of DNA binding • negative regulation of fat cell proliferation • DNA damage checkpoint • cellular response to xenobiotic stimulus • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • regulation of cell cycle • positive regulation of transcription, DNA-templated • regulation of G1/S transition of mitotic cell cycle • mRNA stabilization • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • positive regulation of gene expression • cellular response to fatty acid • anoikis • spermatogenesis • intrinsic apoptotic signaling pathway in response to DNA damage • intrinsic apoptotic signaling pathway by p53 class mediator • cell cycle • forebrain development • negative regulation of transcription, DNA-templated • cellular response to hypoxia • positive regulation of transcription from RNA polymerase II promoter • apoptotic process • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1869	13555
Ensembl	ENSG00000101412	ENSMUSG00000027490
UniProt	Q01094	Q61501
RefSeq (mRNA)	NM_005225	NM_007891 NM_001291105
RefSeq (protein)	NP_005216	NP_031917.1 NP_001278034 NP_031917
Location (UCSC)	Chr 20: 33.68 – 33.69 Mb	Chr 2: 154.56 – 154.57 Mb
PubMed search

1H24, 1O9K, 2AZE

1869

13555

ENSG00000101412

ENSMUSG00000027490

Q01094

Q61501

NM_005225

NM_007891
NM_001291105

NP_005216

NP_031917.1
NP_001278034
NP_031917

Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene.

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.

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