Francis V, Duke of Modena, Reggio and Guastalla, Archduke of Austria-Este, Royal Prince of Hungary and Bohemia, Duke of Modena, Reggio, and Mirandola, Duke of Guastalla, Duke of Massa, Prince of Carrara (Italian: Francesco Ferdinando Geminiano de Asburgo-Lotaringia; 1 June 1819 – 20 November 1875) was a reigning . He was Duke of Modena, Reggio, and Mirandola, Duke of Guastalla from 1847 and Duke of Massa and Prince of Carrara from 1846 to 1859. His parents were Francis IV of Modena and Princess Maria Beatrice of Savoy. He was the last reigning Duke of Modena before the duchy was incorporated into the Kingdom of Italy.

Francis was baptised 5 days after birth by the local Archbishop in the local Cathedral; Emperor Franz I of Austria, the former Holy Roman Emperor, acted as his godfather, but his uncle Archduke Ferdinand acted as proxy for the emperor.

In 1826 Francis IV of Modena appointed Count Clemente Coronini as tutor to Francis, with Don Pietro Raffaelli, who would later become Bishop of Carpi and Reggio, as his assistant. In 1829, Baron Ernest Geramb became Francis' new tutor.