Duchess Charlotte Georgine Luise Friederike of Mecklenburg-Strelitz (17 November 1769 – 14 May 1818) was a member of the House of Mecklenburg-Strelitz and a Duchess of Mecklenburg-Strelitz by birth and a Duchess of Saxe-Hildburghausen through her marriage to Frederick, Duke of Saxe-Hildburghausen (later Duke of Saxe-Altenburg).

Charlotte Georgine was born in Hanover, Electorate of Brunswick-Lüneburg. She was the eldest child and daughter of Charles II, Grand Duke of Mecklenburg and his first wife Princess Friederike of Hesse-Darmstadt.

Charlotte and her sisters, Queen Louise of Prussia, Queen Frederica of Hannover and Princess Therese of Thurn und Taxis, were considered the most beautiful women of their time. Jean Paul Friedrich Richter dedicated his novel "Titan" to the four beautiful and noble sisters on the throne.

Charlotte grew up in Hanover, where her father served as governor, on behalf of his brother-in-law, King George III of the United Kingdom, who lived in London. When Charlotte was twelve years old, her mother died and she was brought up by her mother's sister, Charlotte, who married her father in 1784, and also by Magdalena of Wolzogen. Her sisters were brought by her grandmother, Maria Louise Albertine of Leiningen-Falkenburg-Dagsburg in Darmstadt. Charlotte had then already moved to Hildburghausen.

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