Princess Charlotte Luise Friederike Amalie Alexandrine of Saxe-Hildburghausen, full German name: Charlotte Luise Friederike Amalie Alexandrine, Prinzessin von Sachsen-Hildburghausen (28 January 1794, Hildburghausen, Saxe-Hildburghausen – 6 April 1825, Biebrich, Duchy of Nassau) was a member of the House of Saxe-Hildburghausen and a Princess of Saxe-Hildburghausen (and later of Saxe-Altenburg) by birth. Through her marriage to William, Duke of Nassau, Louise was also a member of the House of Nassau-Weilburg and Duchess consort of Nassau. Louise was briefly Princess consort of Nassau-Weilburg in 1816.

Louise was the seventh child of Frederick, Duke of Saxe-Hildburghausen and his wife Duchess Charlotte Georgine of Mecklenburg-Strelitz. One of her godparents were her aunt, Louise of Mecklenburg-Strelitz, Queen consort of Kingdom of Prussia. Louise and her sister Therese were considered very beautiful, and were the subject of the Friedrich Rückert poem “Mit drei Moosrosen."

In 1809, Ludwig, Crown Prince of Bavaria visited Schloss Hildburghausen to choose his bride. Ludwig chose between Louise and Therese and finally selected Therese. Louise married William, Duke of Nassau, eldest son of Frederick William, Prince of Nassau-Weilburg and his wife Burgravine Louise Isabelle of Kirchberg, on 24 June 1814 in Weilburg. To honor the occasion of their marriage, the Civil Guard of Weilberg and Samuel Luja (1735–1818) composed the "Cantate am Feste der Heimführung des Erbprinzen Wilhelm von Nassau mit der Prinzessin Louise von Sachsen-Hildburghausen."

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